Ninjurin1 (Ninj1) is a double-transmembrane cell surface protein that could promote nerve regeneration in the process of the peripheral nervous system injury and repairment. Nonetheless, the accurate function of Ninj1 in the central nervous system and outside the nervous system is not completely clear. According to the recent studies, we found that Ninj1 is also aberrantly expressed in various pathophysiological processes in vivo, including inflammation, tumorigenesis, and vascular, bone, and muscle homeostasis. These findings suggest that Ninj1 may play an influential role during these pathophysiological processes. Our review summarizes the diverse roles of Ninj1 in multiple pathophysiological processes inside and outside the nervous system. Ninj1 should be considered as an important and novel therapeutic target in certain diseases, such as inflammatory diseases and ischemic diseases. Our study provided a better understanding of Ninj1 in different pathophysiological processes and thereby provided the theoretical support for further research.
Dev Neurosci

中文翻译：

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Ninjurin1 的作用及其对神经系统以外的影响

Ninjurin1（Ninj1）是一种双跨膜细胞表面蛋白，在周围神经系统损伤和修复过程中可以促进神经再生。尽管如此，Ninj1在中枢神经系统和神经系统外的准确功能尚不完全清楚。根据最近的研究，我们发现 Ninj1 在体内各种病理生理过程中也异常表达，包括炎症、肿瘤发生以及血管、骨骼和肌肉稳态。这些发现表明 Ninj1 可能在这些病理生理过程中发挥重要作用。我们的综述总结了 Ninj1 在神经系统内外的多种病理生理过程中的不同作用。Ninj1 应被视为某些疾病的重要且新颖的治疗靶点，如炎症性疾病和缺血性疾病。我们的研究为Ninj1在不同病理生理过程中提供了更好的理解，从而为进一步研究提供了理论支持。
开发神经科学