当前位置: X-MOL 学术Environ. Sci. Pollut. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Role of UPP pathway in amelioration of diabetes-associated complications
Environmental Science and Pollution Research ( IF 5.8 ) Pub Date : 2021-03-03 , DOI: 10.1007/s11356-021-12781-5
Amit Gupta , Tapan Behl , Lotfi Aleya , Md. Habibur Rahman , Harlokesh Narayan Yadav , Giridhari Pal , Ishnoor Kaur , Sandeep Arora

Type 2 diabetes (T2D) is one of the most widely spread metabolic disorder also called as “life style” disease. Due to the alarming number of patients, there is great need to therapies targeting functions which can help in maintaining the homeostasis of glucose levels and improving insulin sensitivity. Detailed analysis was done through various research and review papers which was searched using MEDLINE, BIOSIS, and EMBASE using various keywords. This search retrieved the most appropriate content on these molecules targeting UPP pathway. From this extensive review involving UPP pathway, it was concluded that the role of ubiquitin’s is not only limited to neurodegenerative disorders but also plays a critical role in progression of diabetes including obesity, insulin resistance, and various neurogenerative disorders but it also targets proteasomal degradation including mediation of cellular signaling pathways. Thus, drugs targeting UPP not only may show effect against diabetes but also are therapeutically beneficial in the treatment of diabetes-associated complications which may be obtained. Thus, based on the available information and data on UPP functions, it can be concluded that regulation of UPP pathway via downstream regulators mainly E1, E2, and E3 may bring promising results. Drugs targeting these transcriptional factors may emerge as a novel therapy in the treatment of diabetes and diabetes-associated complications.



中文翻译:

UPP途径在改善糖尿病相关并发症中的作用

2型糖尿病(T2D)是最广泛传播的代谢性疾病之一,也被称为“生活方式”疾病。由于患者数量惊人,因此迫切需要针对功能的疗法,以帮助维持血糖水平的稳态和改善胰岛素敏感性。通过各种研究和评论论文进行了详细的分析,这些论文使用MEDLINE,BIOSIS和EMBASE使用各种关键字进行搜索。该搜索检索了靶向UPP途径的这些分子上最合适的内容。从涉及UPP途径的广泛综述中可以得出结论,泛素的作用不仅限于神经退行性疾病,而且在包括肥胖症,胰岛素抵抗,和各种神经发生性疾病,但它也以蛋白酶体降解为目标,包括介导细胞信号通路。因此,靶向UPP的药物不仅可以显示出抗糖尿病作用,而且在治疗可能获得的糖尿病相关并发症方面具有治疗上的益处。因此,根据有关UPP功能的可用信息和数据,可以得出结论,通过下游调节器(主要是E1,E2和E3)调节UPP途径可能会带来令人鼓舞的结果。靶向这些转录因子的药物可能会作为治疗糖尿病和糖尿病相关并发症的新疗法而出现。靶向UPP的药物不仅可能显示出抗糖尿病作用,而且在治疗可能获得的糖尿病相关并发症方面也具有治疗优势。因此,根据有关UPP功能的可用信息和数据,可以得出结论,通过下游调节器(主要是E1,E2和E3)调节UPP途径可能会带来令人鼓舞的结果。靶向这些转录因子的药物可能会作为治疗糖尿病和糖尿病相关并发症的新疗法而出现。靶向UPP的药物不仅可能显示出抗糖尿病作用,而且在治疗可能获得的糖尿病相关并发症方面具有治疗优势。因此,根据有关UPP功能的可用信息和数据,可以得出结论,通过下游调节器(主要是E1,E2和E3)调节UPP途径可能会带来令人鼓舞的结果。靶向这些转录因子的药物可能会作为治疗糖尿病和糖尿病相关并发症的新疗法而出现。

更新日期:2021-03-03
down
wechat
bug