Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans.

Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed.

Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups.

Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neurodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.

简介：本研究描述了以社区为基础的墨西哥裔美国人样本中血浆 NfL 与认知之间的关系。

方法：544 名参与者完成了一系列神经心理学测试，并使用临床标准进行诊断。NfL 使用 Simoa 测定。分析了跨组和测试的 NfL 水平。

结果：在正常组和受损组之间发现了 NfL 的差异，并且与全局认知、处理速度、执行功能和一系列学习任务有关，对所有诊断组都有显着的负面影响。NfL 对正常组和 MCI 组的处理速度、注意力、执行功能以及延迟和识别记忆都有负面影响。

结论：该研究支持血浆 NfL 作为与墨西哥裔美国人神经退行性过程相关的认知障碍的标志物，并且可能是认知正常和有发生 MCI 风险的人早期认知变化的标志物。