This study aimed to explore the application value of nalbuphine in pulsed radiofrequency operation of trigeminal ganglion in patients with postherpetic neuralgia (PHN). Thirty patients with PHN were randomly divided into the nalbuphine (Nalbu) group and ketorolac tromethamine (KT) group and received CT-guided pulsed radiofrequency surgery on trigeminal ganglion. The numeric rating scale (NRS) scores of patients were recorded at preoperative, intraoperative, and postoperative time points, before going to bed, and the next morning after the operation. In addition, the number of breakthrough pain before operation and within 24 hours after operation, the incidence of nausea and vomiting within 24 hours after surgery, and the patient’s sleep quality before and on the day after surgery were evaluated. The outcome data demonstrated that patients treated with nalbuphine had lower NRS scores after the pulse radiofrequency operation during and after the pulse radiofrequency operation compared to those with KT. In addition, nalbuphine effectively decreased the number of breakthrough pain, reduced the occurrence of nausea and vomiting after surgery, and improved the sleep quality. In conclusion, intramuscular injection of nalbuphine 30 min before trigeminal ganglion pulse radiofrequency surgery can be conducive to pain relief and improve the postoperative comfort of patients, providing an effective alternative for the alleviation of PHN in clinic.

中文翻译：

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纳布啡在带状疱疹后神经痛患者三叉神经节脉冲射频手术中的应用

本研究旨在探讨纳布啡在带状疱疹后神经痛（PHN）患者三叉神经节脉冲射频手术中的应用价值。将30例PHN患者随机分为纳布啡（Nalbu）组和酮咯酸三甲胺（KT）组，并在三叉神经节上接受CT引导的脉冲射频手术。记录患者的术前，术中和术后时间点的数字评分量表（NRS）得分，分别于入睡前和术后第二天早晨。此外，还评估了术前和术后24小时内突破性疼痛的次数，术后24小时内恶心和呕吐的发生率以及术后前后的患者睡眠质量。结果数据表明，与KT组相比，接受纳布啡治疗的患者在脉冲射频手术期间和之后的脉冲射频手术后的NRS评分较低。此外，纳布啡有效减少了突破性疼痛的次数，减少了术后恶心和呕吐的发生，并改善了睡眠质量。综上所述，三叉神经节脉冲射频手术前30min肌注纳布啡可有助于缓解疼痛，改善患者的术后舒适度，为缓解临床PHN提供了有效的替代方法。纳布啡有效地减少了突破性疼痛的次数，减少了手术后恶心和呕吐的发生，并改善了睡眠质量。综上所述，三叉神经节脉冲射频手术前30min肌注纳布啡可有利于缓解疼痛，提高患者术后舒适度，为临床缓解PHN提供了有效的替代方法。纳布啡有效减少了突破性疼痛的数量，减少了手术后恶心和呕吐的发生，并改善了睡眠质量。综上所述，三叉神经节脉冲射频手术前30min肌注纳布啡可有利于缓解疼痛，提高患者术后舒适度，为临床缓解PHN提供了有效的替代方法。