Introduction: Amlyopia always presents with monocular and binocular dysfunction. In this study, we aim to investage the efficacy of alternative occlusion using liquid crystal glasses versus continuous occlusion therapy using traditional patches for treating amblyopia. Methods: Eligible subjects with anisometropic amblyopia were randomized into two groups: alternative flicker glass (AFG) or patching group. In the AFG group, subjects were instructed to wear the flicker glasses for 1 hour a day. The AFG is a lightweight spectacle frame with liquid crystal lenses that provide direct square-wave alternating occlusion, which were pre-programmed at temporal frequency of 7Hz. In the patching group, the patients were prescribed to wear traditional patches for 2 hours a day. The best corrected visual acuity (BCVA), contrast sensitivity function (CSF) and stereoacuity were measured at the baseline, 3 and 12 weeks. Results: In this pilot study, a total of forty children were recruited, with twenty in the AFG group. Mean BCVA improved by 0.17±0.14logMAR (95% CI=0.10 to 0.23) in the AFG group, while 0.18±0.18logMAR (95% CI=0.09 to 0.26) in the patching group from baseline to 12 weeks. The improvement of BCVA in both groups were significant (both P＜0.01), while no significant difference between the groups (P=0.82). The CSF of both low and high spatial frequencies exhibited significant improvement at 12 weeks in the AFG group (P＜0.01, respectively), while just have a significant improvement at low spatial frequency in the patching group (P＜0.01). The stereoacuity significantly improved by 504.00±848.00 (95% CI= -900.88 to -107.12) arc seconds in the AFG group (P＜0.05), while 263.50± 639.55 (95% CI=-562.82 to 35.82) arc seconds in the patching group (P＞0.05). Conclusion: Alternative flicker glass was effective in improving both monocular and binocular function, which was most likely achieved by reducing the suppression and promoting binocular fusion. This therapy exhibited promise as an alternative method for amblyopia treatment.


中文翻译：

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替代闪烁玻璃：一种治疗屈光参差性弱视的新抗抑制方法

简介：弱视总是表现为单眼和双眼功能障碍。在这项研究中，我们旨在研究使用液晶眼镜的替代遮挡与使用传统贴片治疗弱视的连续遮挡疗法的疗效。方法：符合条件的屈光参差性弱视受试者被随机分为两组：替代闪烁玻璃 (AFG) 或贴片组。在 AFG 组中，受试者被要求每天佩戴闪烁眼镜 1 小时。AFG 是一种带有液晶镜片的轻型眼镜架，可提供直接的方波交替遮挡，并以 7Hz 的时间频率进行预编程。在贴片组中，患者被要求每天佩戴传统贴片 2 小时。最佳矫正视力（BCVA），在基线、第 3 周和第 12 周时测量对比敏感度功能 (CSF) 和立体视觉。结果：在这项试点研究中，共招募了 40 名儿童，其中 AFG 组中有 20 名儿童。从基线到 12 周，AFG 组的平均 BCVA 改善了 0.17±0.14logMAR（95% CI=0.10 到 0.23），而修补组的平均 BCVA 改善了 0.18±0.18logMAR（95% CI=0.09 到 0.26）。两组BCVA改善均有显着性意义（均P＜0.01），组间差异无统计学意义（P=0.82）。AFG组12周时低、高空间频率的CSF均有显着改善（分别P＜0.01），而贴片组仅在低空间频率有显着改善（P＜0.01）。立体视度显着提高 504.00±848.00 (95% CI= -900.88 to -107. 12）AFG组为弧秒（P＜0.05），而修补组为263.50±639.55（95% CI=-562.82～35.82）弧秒（P＞0.05）。结论：替代闪烁玻璃可有效改善单眼和双眼功能，这很可能是通过减少抑制和促进双眼融合来实现的。这种疗法有望成为弱视治疗的替代方法。