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Allostatic load: Developmental and conceptual considerations in a multi-system physiological indicator of chronic stress exposure
Developmental Psychobiology ( IF 2.2 ) Pub Date : 2021-03-01 , DOI: 10.1002/dev.22107
Stacey N Doan 1
Affiliation  

Developmental researchers studying how stress affects health have often focused on specific, individual, physiological parameters such as cortisol. Yet, recent theories of stress biology emphasize that the stress response is multi-faceted and engages distinct yet interconnected physiological systems, including metabolic, immune, and cardiovascular systems that respond to one another. Moreover, advocates of a systems approach also argue that the confluence of changes across several physiological systems presents a health risk, even when one indicator alone is not predictive of health outcomes. Allostatic load is one potential multi-system indicator of stress, capturing the cumulative, physiological burden of chronic stress exposure on the body. At the same time, studying allostatic load during early development raises several issues, including how allostatic load is operationalized, the clinical importance of commonly used biomarkers during distinct periods of development, and the fundamental role of timing. In this review paper, we discuss the potential of allostatic load in the context of studies of stress in developmental science, review developmental studies that have assessed allostatic load, and articulate critical conceptual questions regarding the study of allostatic load during the childhood years.

中文翻译:

静力负荷:慢性压力暴露的多系统生理指标中的发展和概念考虑

研究压力如何影响健康的发育研究人员通常关注特定的、个体的生理参数,例如皮质醇。然而,最近的压力生物学理论强调,压力反应是多方面的,涉及不同但相互关联的生理系统,包括相互反应的代谢、免疫和心血管系统。此外,系统方法的倡导者还认为,多个生理系统的变化汇合会带来健康风险,即使仅一个指标不能预测健康结果。静力负荷是一种潜在的多系统压力指标,可捕捉身体慢性压力暴露的累积生理负担。同时,研究早期开发过程中的异静载荷提出了几个问题,包括如何对负载进行操作,常用生物标志物在不同发育时期的临床重要性,以及时间的基本作用。在这篇评论文章中,我们讨论了在发育科学中压力研究的背景下异动负荷的潜力,回顾了评估异动负荷的发育研究,并阐明了有关儿童时期异动负荷研究的关键概念问题。
更新日期:2021-03-01
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