Foot deformities are frequently observed in patients with Charcot Marie tooth disease (CMT) and orthopaedic surgery is often required. Currently there is no evidence-based guideline on surgical management and only a few studies which have evaluated long-term outcomes of surgical procedures. The aim of the study was to evaluate longitudinally the effect of foot surgery in a cohort of CMT patients. Twenty-five CMT adult patients were assessed using a comprehensive group of validated scales and questionnaires before and after surgery. A wide range of surgical procedures was performed by one team of dedicated foot ankle orthopaedic surgeons. Foot alignment as measured by the foot posture index, pain, quality of life and callosities significantly improved after one year and the improvement was maintained up to 4 years after surgery. There was a trend towards a reduction in the number of falls post-operatively. Surgery had no effect on fatigue, balance and CMT examination score. Our findings showed significant improvement of pain, foot alignment, callosities and quality of life after surgery and suggested that foot deformity correction in adults with CMT performed in a specialised foot and ankle unit is beneficial.

中文翻译：

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Charcot Marie牙病足畸形手术治疗的前瞻性研究

在 Charcot Marie 牙病 (CMT) 患者中经常观察到足部畸形，并且通常需要进行矫形手术。目前还没有关于外科手术管理的循证指南，只有少数研究评估了外科手术的长期结果。该研究的目的是纵向评估足部手术对一组 CMT 患者的影响。25 名 CMT 成年患者在手术前后使用一组经过验证的综合量表和问卷进行了评估。一个专门的足踝骨科医生团队进行了广泛的外科手术。通过足部姿势指数、疼痛、生活质量和胼胝体测量的足部排列在一年后显着改善，并且这种改善在手术后保持长达 4 年。术后跌倒次数有减少的趋势。手术对疲劳、平衡和CMT检查评分无影响。我们的研究结果显示，术后疼痛、足部对齐、胼胝体和生活质量得到显着改善，并表明在专门的足部和踝部进行的 CMT 成人足部畸形矫正是有益的。