In recent years, neurodegeneration has been recognized as a clinical condition that is characterized by neuronal death, dementia, and gradual diminish of cognitive function, poor body coordination and motor disorders. Several studies deciphering cellular and molecular mechanisms show a promising insight for several kinds of damages including neurodegeneration in central nervous system. In addition, there has been an inflammatory key mechanism involved in neurodegenerative disorders. There is a paucity of literature in both cellular- and molecular-mediated targets in damaged neurons at both in vitro and in vivo research models. It has been notified that CNS has a very restricted magnitude of regeneration. Numerous key factors have also been studied and considered as possible culprit of neurodegeneration. Autophagy is a well-known degradation process wherein vesicular machinery as autophagosome transports cytoplasmic contents to the lysosomes. In earlier reports, a bridging connection between autophagy and its associated mechanism has been established. Natural compounds as a neuro-therapeutics have been recognized in neurodegeneration. In our review, we discuss the mechanisms for the onset and progression in neurodegeneration, via inflammation and autophagic machine available in cellular compartments in CNS. This review also discusses about the neuroprotective efficacy of natural compounds against neurodegeneration episodes displays in neuronal platform.

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神经退行性疾病的细胞和分子机制：神经保护剂的可能作用

近年来，神经变性被认为是一种以神经元死亡、痴呆、认知功能逐渐减退、身体协调性差和运动障碍为特征的临床病症。几项破译细胞和分子机制的研究显示了对包括中枢神经系统神经变性在内的几种损伤的有希望的见解。此外，在神经退行性疾病中还存在一种炎症关键机制。在体外和体内研究模型中，关于受损神经元中细胞和分子介导的靶标的文献都很少。据了解，CNS 的再生量非常有限。许多关键因素也被研究并被认为是神经退行性疾病的可能罪魁祸首。自噬是众所周知的降解过程，其中作为自噬体的囊泡机器将细胞质内容物运输到溶酶体。在早期的报告中，已经建立了自噬与其相关机制之间的桥梁联系。作为神经治疗剂的天然化合物已在神经退行性疾病中得到认可。在我们的综述中，我们通过中枢神经系统细胞区室中可用的炎症和自噬机器讨论了神经变性的发生和进展机制。本综述还讨论了天然化合物对神经元平台中神经变性发作的神经保护功效。自噬与其相关机制之间建立了桥梁联系。作为神经治疗剂的天然化合物已在神经退行性疾病中得到认可。在我们的综述中，我们通过中枢神经系统细胞区室中可用的炎症和自噬机器讨论了神经变性的发生和进展机制。本综述还讨论了天然化合物对神经元平台中神经变性发作的神经保护功效。自噬与其相关机制之间建立了桥梁联系。作为神经治疗剂的天然化合物已在神经退行性疾病中得到认可。在我们的综述中，我们通过中枢神经系统细胞区室中可用的炎症和自噬机器讨论了神经变性的发生和进展机制。本综述还讨论了天然化合物对神经元平台中神经变性发作的神经保护功效。