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Integrated analysis of the prognostic values of RNA-binding proteins in head and neck squamous cell carcinoma
Biofactors ( IF 6 ) Pub Date : 2021-03-02 , DOI: 10.1002/biof.1722
Zeng-Hong Wu 1, 2 , Jian-Xin Yue 1 , Tao Zhou 1 , Hong-Jun Xiao 1
Affiliation  

Head and neck squamous cell carcinoma is a malignant tumor of the upper aerodigestive tract. These RNA-binding proteins (RBPs) influence post-transcriptional in cells and regulate cell physiology, participate in regulating RNA stability, alternative splicing, translation, modification, localization, and apoptosis. We used RNA sequencing data from The Cancer Genome Atlas to display dysfunctional RBPs microenvironments and provide potential useful biomarkers for head and neck squamous cell carcinoma (HNSCC) diagnosis and prognosis. Six RBPs (DNMT1, PCF11, EIF5A2, RNASE10, PSMA6, and IGF2BP2) were selected as independent prognosis factors of HNSCC patients. The Kyoto Encyclopedia of Genes and Genomes were mainly enriched in RNA transport, Spliceosome, RNA degradation, mRNA surveillance pathway, and Epstein–Barr virus infection. cBioPortal results demonstrated that these six genes were altered in 150 samples out of 504 HNSCC patients (30%) and the amplification of IGF2BP2 was the largest frequent copy-number alteration. Based on the online database, we identified novel RBPs markers for the prognosis of HNSCC.

中文翻译:

RNA结合蛋白对头颈部鳞状细胞癌预后价值的综合分析

头颈部鳞状细胞癌是上呼吸消化道的恶性肿瘤。这些 RNA 结合蛋白 (RBP) 影响细胞中的转录后并调节细胞生理学,参与调节 RNA 稳定性、选择性剪接、翻译、修饰、定位和细胞凋亡。我们使用来自癌症基因组图谱的 RNA 测序数据来显示功能失调的 RBP 微环境,并为头颈部鳞状细胞癌 (HNSCC) 的诊断和预后提供潜在有用的生物标志物。六个RBPDNMT1PCF11EIF5A2RNASE10PSMA6IGF2BP2) 被选为 HNSCC 患者的独立预后因素。京都基因和基因组百科全书主要丰富了 RNA 转运、剪接体、RNA 降解、mRNA 监视途径和 Epstein-Barr 病毒感染。cBioPortal 结果表明,这 6 个基因在 504 名 HNSCC 患者(30%)中的 150 个样本中发生了改变,并且IGF2BP2的扩增是最大的频繁拷贝数改变。基于在线数据库,我们确定了用于 HNSCC 预后的新型 RBP 标志物。
更新日期:2021-03-02
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