Cardiovascular disease is the leading cause of death worldwide. The societal health burden it represents can be reduced by taking preventive measures and developing more effective therapies. Reaching these goals, however, requires a better understanding of the pathophysiological processes leading to and occurring in the diseased heart. In the last 5 years, several biological advances applying single-cell technologies have enabled researchers to study cardiovascular diseases with unprecedented resolution. This has produced many new insights into how specific cell types change their gene expression level, activation status and potential cellular interactions with the development of cardiovascular disease, but a comprehensive overview of the clinical implications of these findings is lacking. In this review, we summarize and discuss these recent advances and the promise of single-cell technologies from a translational perspective across the cardiovascular disease continuum, covering both animal and human studies, and explore the future directions of the field.

心血管疾病是全球死亡的主要原因。通过采取预防措施和开发更有效的疗法，可以减轻它所代表的社会健康负担。然而，要达到这些目标，需要更好地了解导致和发生在患病心脏中的病理生理过程。在过去 5 年中，应用单细胞技术的多项生物学进展使研究人员能够以前所未有的分辨率研究心血管疾病。这对特定细胞类型如何改变其基因表达水平、激活状态和潜在的细胞相互作用与心血管疾病的发展产生了许多新的见解，但缺乏对这些发现的临床意义的全面概述。在本次审查中，