Knowledge of the toxic potential of polycyclic aromatic hydrocarbons (PAHs) has increased over time. Much of this knowledge is about the 16 United States - Environmental Protection Agency (US - EPA) priority PAHs; however, there are other US – EPA non-priority PAHs in the environment, whose toxic potential is underestimated. We conducted a systematic review of in vitro, in vivo, and in silico studies to assess the genotoxicity, mutagenicity, and carcinogenicity of 13 US - EPA non-priority parental PAHs present in the environment. Electronic databases, such as Science Direct, PubMed, Scopus, Google Scholar, and Web of Science, were used to search for research with selected terms without time restrictions. After analysis, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, 249 articles, published between 1946 and 2020, were selected and the quality assessment of these studies was performed. The results showed that 5-methylchrysene (5-MC), 7,12-dimethylbenz[a]anthracene (7,12-DMBA), cyclopenta[cd]pyrene (CPP), and dibenzo[al]pyrene (Db[al]P) were the most studied PAHs. Moreover, 5-MC, 7,12-DMBA, benz[j]aceanthrylene (B[j]A), CPP, anthanthrene (ANT), dibenzo[ae]pyrene (Db[ae]P), and Db[al]P have been reported to cause mutagenic effects and have been being associated with a risk of carcinogenicity. Retene (RET) and benzo[c]fluorene (B[c]F), the least studied compounds, showed evidence of a strong influence on the mutagenicity and carcinogenicity endpoints. Overall, this systematic review provided evidence of the genotoxic, mutagenic, and carcinogenic endpoints of US - EPA non-priority PAHs. However, further studies are needed to improve the future protocols of environmental analysis and risk assessment in severely exposed populations.

随着时间的推移，人们对多环芳烃（PAHs）的潜在毒性的认识有所增加。这些知识大部分与16个美国-环境保护局（US-EPA）优先PAH有关；但是，环境中还有其他美国– EPA非优先PAHs，其潜在毒性被低估了。我们对体外，体内和计算机模拟进行了系统的综述评估环境中存在的13种US-EPA非优先亲本PAHs的遗传毒性，诱变性和致癌性的研究。电子数据库，例如Science Direct，PubMed，Scopus，Google Scholar和Web of Science，被用来搜索带有选定术语的研究，而没有时间限制。经过分析，根据系统评价和荟萃分析的首选报告项目（PRISMA）协议，选择了1946年至2020年之间发表的249篇文章，并对这些研究进行了质量评估。结果表明，5-甲基丙烯（5-MC），7,12-二甲基苯并[ a ]蒽（7,12-DMBA），环戊[ cd ] py（CPP）和二苯并[ al ]]（Db [ al]] P）是研究最多的PAH。此外，5-MC，7,12-DMBA，苯并[ j ]乙炔（B [ j ] A），CPP，蒽（ANT），二苯并[ ae ] py（Db [ ae ] P）和Db [ al ]据报道，P会引起诱变作用，并与致癌性有关。t（RET）和苯并[ c ]芴（B [ c] F）（研究最少的化合物）显示出对诱变性和致癌性终点有强烈影响的证据。总的来说，这项系统的综述提供了US-EPA非优先PAHs的遗传毒性，诱变和致癌终点的证据。但是，需要进行进一步的研究以改善未来在严重暴露人群中进行环境分析和风险评估的方案。