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In utero exposure to phthalates and reproductive toxicity in rodents
Best Practice & Research Clinical Endocrinology & Metabolism ( IF 7.4 ) Pub Date : 2021-03-02 , DOI: 10.1016/j.beem.2021.101512
Anastasia Repouskou 1 , Antonios Stamatakis 2 , Efthymia Kitraki 1
Affiliation  

Phthalates, widely used as plasticizers, are contained in many everyday products. Human biomonitoring studies detect their presence in biological fluids of a large part of the population worldwide. Maternal exposure during pregnancy has been related with aberrations in the reproductive growth of male infants. Rodent studies show that gestational exposure to single phthalates elicits reproductive toxicity in both sexes. Early aberrations include inhibition of gonadal sex determining gene expression and steroidogenesis, histopathology, and disturbed gametogenesis, leading later in life to dysfunctions in sperm production and oocyte reserves. Animal studies of in utero exposure to mixtures of phthalates, better mimicking human exposures, revealed analogous reproductive dysfunctions with the single compounds, but also indicated the combined actions and cumulative effects exerted by these chemicals. Further understanding the underlying mechanisms and the species differences in phthalate-induced reproductive toxicity will help to improve the risk assessment for human exposure to these toxicants.



中文翻译:

宫内接触邻苯二甲酸盐和啮齿动物的生殖毒性

邻苯二甲酸盐广泛用作增塑剂,包含在许多日常用品中。人体生物监测研究检测到它们存在于全世界大部分人口的生物体液中。孕期母体暴露与男婴生殖发育异常有关。啮齿动物研究表明,妊娠期暴露于单一邻苯二甲酸盐会引起两性生殖毒性。早期异常包括性腺性别决定基因表达和类固醇生成的抑制、组织病理学和配子发生紊乱,导致生命后期精子生成和卵母细胞储备功能障碍。子宫内动物研究暴露于邻苯二甲酸盐混合物,更好地模拟人类暴露,揭示了与单一化合物类似的生殖功能障碍,但也表明了这些化学物质的联合作用和累积效应。进一步了解邻苯二甲酸酯引起的生殖毒性的潜在机制和物种差异将有助于改进人类暴露于这些毒物的风险评估。

更新日期:2021-03-02
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