This study investigated BCG masking dependency on the species of Mycobacterium through the immune response to the mycobacterial region of deletion 1 (RD-1) associated growth affecting proteins (GEP).To evaluate the effects of GEP, 8-week old female BALB/c mice were immunized with either the wild type Mycobacterium bovis (MBGEP) or the ATCC Mycobacterium avium subsp. avium (MAGEP) strain and then subjected to further exposure with Mycobacterium terrae or M. avium sub. avium. Mice immunized with MAGEP and those mice further exposed to M. avium subsp. avium had increased granulocytes (GRA) and monocytes to lymphocytes rate (MLR) compared to control mice. Immunization of mice with GEP induced an antibody response one month after primary immunization, as observed by cross-reactivity. Our findings suggest that MAGEP is related to a latent hypersensitivity reaction and an increased risk of mycobacterial infection susceptibility. According to the results of the present study, previous sensitization with NTM antigens results in varying immune reactions after contact with different NTM argued that masking phenomena may be dependent on the species of Mycobacterium.

中文翻译：

---

BCG掩盖现象可能取决于分枝杆菌的种类。

本研究通过对缺失1分枝杆菌区域（RD-1）相关生长影响蛋白（GEP）的免疫应答来研究BCG对分枝杆菌物种的掩蔽依赖性。为评估8周龄雌性BALB / c对GEP的影响用野生型牛分枝杆菌（MBGEP）或鸟分枝杆菌ATCC分枝杆菌免疫小鼠。禽（MAGEP）菌株，然后进一步与土分枝杆菌或鸟分枝杆菌亚种接触。阿维姆 用MAGEP免疫的小鼠，这些小鼠进一步暴露于鸟分枝杆菌亚种。与对照小鼠相比，鸟卵中的粒细胞（GRA）和单核细胞与淋巴细胞比率（MLR）增加。交叉反应观察到，初次免疫后一个月，GEP免疫小鼠诱导了抗体反应。我们的发现表明，MAGEP与潜在的超敏反应和分枝杆菌感染易感性增加有关。根据本研究的结果，先前与NTM抗原的致敏作用导致在与不同的NTM接触后产生不同的免疫反应，认为掩盖现象可能取决于分枝杆菌的种类。