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Detection of non-polio and polio enteroviruses in Acute Flaccid Paralysis surveillance in Turkey.
Acta Microbiologica et Immunologica Hungarica ( IF 1.5 ) Pub Date : 2021-02-27 , DOI: 10.1556/030.2021.01353
Gulay Korukluoglu 1 , Umit Ozdemirer 2 , Fatma Bayrakdar 1 , Zehra Unal 3 , Yasemin Cosgun 1 , Tunca Atak 1 , Hulya Karademirtok 1 , Isil Ata 2 , Fatih Kara 4
Affiliation  

Poliomyelitis was a disease feared worldwide, striking suddenly and paralysing mainly children for life. Monitoring of suspected cases of poliomyelitis is carried out with Acute Flaccid Paralysis (AFP) surveillance in Turkey. This study examines national data of AFP surveillance and the epidemiology of enteroviruses (EV) in Turkey from 2000 to 2019 and gives an overview of the detected serotypes of EVs. A total of 13,640 samples collected from patients with 5216 AFP pre-diagnosed cases (2 samples from each patient) and 3,208 contacts, during a 20-year period (2000-2019) were investigated. All isolated polioviruses were tested for their wild or vaccine origin according to the WHO recommended protocol by PCR and sequencing analysis were performed. Enterovirus positivity was detected in a total of 915 cases, which were identified as 204 Sabin-like polio virus (SLPV) and 711 non-polio enterovirus (NPEV). Of the 204 SLPV, 141 (69.1%) AFP were detected in patients and 63 (30.9%) were detected in samples taken from their contacts. Of the 711 NPEVs, 516 (72.5%) were from AFP cases and 195 (27.5%) were detected in samples taken from their contacts. It is concluded that the reason for the higher detection rate of NPEV in samples from AFP pre-diagnosed cases is attributed to the polio vaccination rates reaching 97% between 2008 and 2019 in Turkey. The most frequently detected NPEV serotypes were Coxackie A24, B3, and Echo 30. This retrospective study is the first comprehensive study in Turkey to evaluate the results of the AFP surveillance in the last 20 years.

中文翻译:

土耳其急性弛缓性麻痹监测中非脊髓灰质炎和脊髓灰质炎肠道病毒的检测。

脊髓灰质炎是一种世界范围内令人恐惧的疾病,它突然发作并主要使儿童终生瘫痪。在土耳其,通过急性弛缓性麻痹 (AFP) 监测对疑似脊髓灰质炎病例进行监测。本研究检查了 2000 年至 2019 年土耳其 AFP 监测和肠道病毒 (EV) 流行病学的国家数据,并概述了检测到的 EV 血清型。在 20 年(2000-2019 年)期间,共从 5216 名 AFP 预诊断病例(每位患者 2 个样本)和 3,208 名接触者中收集了 13,640 份样本。所有分离的脊髓灰质炎病毒都根据 WHO 推荐的 PCR 方案进行了野生或疫苗来源的检测,并进行了测序分析。共检测出肠道病毒阳性 915 例,被鉴定为204种萨宾样脊髓灰质炎病毒(SLPV)和711种非脊髓灰质炎肠道病毒(NPEV)。在 204 例 SLPV 中,141 例(69.1%)在患者中检测到 AFP,63 例(30.9%)在从其接触者采集的样本中检测到。在 711 例 NPEV 中,516 例(72.5%)来自 AFP 病例,195 例(27.5%)在从其接触者采集的样本中检测到。得出的结论是,在 AFP 预诊断病例的样本中,NPEV 检出率较高的原因是土耳其在 2008 年至 2019 年间脊髓灰质炎疫苗接种率达到了 97%。最常检测到的 NPEV 血清型是 Coxackie A24、B3 和 Echo 30。这项回顾性研究是土耳其第一个评估过去 20 年 AFP 监测结果的综合研究。1%) 在患者中检测到 AFP,在从其接触者采集的样本中检测到 63 例(30.9%)。在 711 例 NPEV 中,516 例(72.5%)来自 AFP 病例,195 例(27.5%)在从其接触者采集的样本中检测到。得出的结论是,在 AFP 预诊断病例的样本中,NPEV 检出率较高的原因是土耳其在 2008 年至 2019 年间脊髓灰质炎疫苗接种率达到了 97%。最常检测到的 NPEV 血清型是 Coxackie A24、B3 和 Echo 30。这项回顾性研究是土耳其第一个评估过去 20 年 AFP 监测结果的综合研究。1%) 在患者中检测到 AFP,在从其接触者采集的样本中检测到 63 例(30.9%)。在 711 例 NPEV 中,516 例(72.5%)来自 AFP 病例,195 例(27.5%)在从其接触者采集的样本中检测到。得出的结论是,在 AFP 预诊断病例的样本中,NPEV 检出率较高的原因是土耳其在 2008 年至 2019 年间脊髓灰质炎疫苗接种率达到了 97%。最常检测到的 NPEV 血清型是 Coxackie A24、B3 和 Echo 30。这项回顾性研究是土耳其第一个评估过去 20 年 AFP 监测结果的综合研究。得出的结论是,在 AFP 预诊断病例的样本中,NPEV 检出率较高的原因是土耳其在 2008 年至 2019 年间脊髓灰质炎疫苗接种率达到了 97%。最常检测到的 NPEV 血清型是 Coxackie A24、B3 和 Echo 30。这项回顾性研究是土耳其第一个评估过去 20 年 AFP 监测结果的综合研究。得出的结论是,在 AFP 预诊断病例的样本中,NPEV 检出率较高的原因是土耳其在 2008 年至 2019 年间脊髓灰质炎疫苗接种率达到了 97%。最常检测到的 NPEV 血清型是 Coxackie A24、B3 和 Echo 30。这项回顾性研究是土耳其第一个评估过去 20 年 AFP 监测结果的综合研究。
更新日期:2021-03-03
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