Persea americana (PA) is a popular medicinal plant in folkloric medicines. The present study therefore investigates the ameliorative potentials of its leaves extract on carbon tetrachloride and rifampicin-induced toxicity in the liver, kidney and heart of albino rat. This was aimed at assessing the potentials of the plant in the management of liver, kidney and heart diseases. Forty (40) rats were randomly divided into eight (8) groups of five animals each. Groups I and II were administered with only distilled water and carbon tetrachloride (CCl4) respectively. Groups III and IV animals received 3.0 ml/kg bw of CCl4 and were treated with the extract at 50 mg/kg bw and 100 mg/kg respectively, while group V received 100 mg/kg bw. of silymarin orally for 14 days. Groups VI animals were administered with rifampicin (250 mg/kg bw.) only, while groups VII and VIII animals received rifampicin and were treated with 50 mg and 100 mg/kg bw of the extract respectively. Activities of creatine kinase, aspartate amino transferase, alanine amino transferase, alkaline phosphatase, superoxide dismutase, catalase as well as levels of urea, uric acid, bilirubin and malonidialdehyde (MDA) were assayed. Lipid profiles and histopathological examination of liver and kidney slices were also performed. Treatment with P. americana significantly (p < 0.05) restored all deranged biochemical parameters (creatine kinase, aspartate amino transferase, alanine amino transferase, alkaline phosphatase, urea, uric acid, bilirubin, MDA, lipid profile as well as superoxide dismutase and catalase) in a dose-dependent manner. Normal hepatic and renal histoarchitecture were also restored following treatment with P. americana. Amelioration of distorted cardiac, hepatic and renal histoarchitecture as well as restoration of lipid profile, biomarkers of liver and kidney injury and antioxidant enzymes (catalase and superoxide dismutase) affirm the potential usefulness of P. americana in the management of liver, kidney and heart diseases.

中文翻译：

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美洲紫苏叶提取物对有毒物质诱导的wistar白化病大鼠多个器官的氧化攻击的改善潜力。

Persea americana（PA）是民俗医学中流行的药用植物。因此，本研究调查了其叶提取物对四氯化碳和利福平诱导的对白化病大鼠肝，肾和心脏的毒性的改善潜力。目的是评估该植物在治疗肝，肾和心脏疾病中的潜力。四十（40）只大鼠随机分为八（8）组，每组五只。组I和组II仅分别使用蒸馏水和四氯化碳（CCl4）。III和IV组动物接受3.0 ml / kg bw的CCl4，分别以50 mg / kg bw和100 mg / kg的提取物处理，而V组则接受100 mg / kg bw。口服水飞蓟素14天。第六组的动物只接受了利福平（250 mg / kg体重），VII和VIII组动物接受利福平，分别用50 mg / kg和100 mg / kg bw的提取物处理。测定了肌酸激酶，天冬氨酸氨基转移酶，丙氨酸氨基转移酶，碱性磷酸酶，超氧化物歧化酶，过氧化氢酶以及尿素，尿酸，胆红素和丙二醛（MDA）的活性。还进行了肝脏和肾脏切片的脂质分布和组织病理学检查。美洲P.处理显着（p <0.05）恢复了所有紊乱的生化参数（肌酸激酶，天冬氨酸氨基转移酶，丙氨酸氨基转移酶，碱性磷酸酶，尿素，尿酸，胆红素，MDA，脂质分布以及超氧化物歧化酶和过氧化氢酶）以剂量依赖的方式。用美洲P.治疗后，正常的肝和肾组织结构也得以恢复。改善心脏，肝脏和肾脏组织结构的畸变以及脂质分布的恢复，肝肾损伤的生物标志物和抗氧化酶（过氧化氢酶和超氧化物歧化酶）证实美洲假单胞菌在管理肝，肾和心脏病方面的潜在用途。