Current HIV Research ( IF 1 ) Pub Date : 2021-02-28 , DOI: 10.2174/1570162x18666201026143200 Yin Yueqi 1 , Zhou Ying 2 , Lu Jing 2 , Guo Hongxiong 2 , Chen Jianshuang 1 , Xuan Yan 1 , Cheng Hao 3 , Yuan Defu 1 , Hu Haiyang 2 , Xu Xiaoqin 2 , Wang Bei 1 , Fu Gengfeng 2
|
Background: CRF01_AE and CRF07_BC are the two major HIV-1 virus strains circulating in China. The proportion of dominant subtypes (CRF01_AE and CRF07_BC) among MSM in Jiangsu province was over 80%. A large number of URFs have been found in China in recent years.
Objective: This study aimed to report on novel HIV-1 recombinants.
Methods: We constructed Phylogenetic trees using the maximum likelihood (ML) method with 1000 bootstrap replicates in IQ-TREE 1.6.8 software and determined recombination breakpoints using SimPlot 3.5.1.
Results: We identified a novel, second-generation HIV-1 recombinant (JS020202) between CRF01_ AE and CRF07_BC. The analysis of near full-length genome (NFLG) showed there were at least 8 breakpoints in the virus, which differed from any previously identified CRF and URF around the world.
Conclusion: Novel diverse CRF01_AE/07_BC suggested the complexity trends of HIV-1 genetics. The emergency situation of diverse recombinant strains should be monitored continuously.
京公网安备 11010802027423号