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From Genome-Wide to Environment-Wide: Capturing the Environome
Perspectives on Psychological Science ( IF 12.6 ) Pub Date : 2021-03-01 , DOI: 10.1177/1745691620979803
Sophie von Stumm 1 , Katrina d'Apice 1
Affiliation  

Genome-wide association (GWA) studies have shown that genetic influences on individual differences in affect, behavior, and cognition are driven by thousands of DNA variants, each with very small effect sizes. Here, we propose taking inspiration from GWA studies for understanding and modeling the influence of the environment on complex phenotypes. We argue that the availability of DNA microarrays in genetic research is comparable with the advent of digital technologies in psychological science that enable collecting rich, naturalistic observations in real time of the environome, akin to the genome. These data can capture many thousand environmental elements, which we speculate each influence individual differences in affect, behavior, and cognition with very small effect sizes, akin to findings from GWA studies about DNA variants. We outline how the principles and mechanisms of genetic influences on psychological traits can be applied to improve the understanding and models of the environome.



中文翻译:

从全基因组到全环境:捕获环境组

全基因组关联 (GWA) 研究表明,遗传对情感、行为和认知方面的个体差异的影响是由数以千计的 DNA 变异驱动的,每一种变异的影响都非常小。在这里,我们建议从 GWA 研究中汲取灵感,以了解和模拟环境对复杂表型的影响。我们认为,基因研究中 DNA 微阵列的可用性可与心理科学中数字技术的出现相媲美,这些技术能够实时收集环境组的丰富、自然的观察,类似于基因组。这些数据可以捕获数千个环境元素,我们推测每种环境元素都会影响个体在情感、行为和认知方面的差异,但影响大小非常小,类似于 GWA 关于 DNA 变异的研究结果。

更新日期:2021-03-01
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