The objective of the present study is to formulate the bilayer hydrogel of Aceclofenac and Itraconazole followed by surface spray coating with citric acid to treat inflammation, oral candidiasis, and xerostomia conditions in HIV patients. The hydrogel was prepared by the chemical cross-linking method using polyvinyl alcohol as polymer at the concentrations of 3%, 5%, 7%, and 9% w/v, for both the individual drugs and the combination bilayer. The amount of cross-linking agent (glutaraldehyde 1% v/v) and the catalyst (concentrated hydrochloric acid [HCl], dilute HCl, and acetic acid) was optimized at the level of 0.1 mL each in every hydrogel system, based on the required physical properties. The hydrogels were subjected for various evaluation parameters like weight variation (0.054–0.300 g), diameter (9.5–12.5 mm), thickness (2.5–4.0 mm), drug content (2.5–2.8 mg/mL), and swelling study. The increase in the polymer composition had led to a significant increase in the thickness and weight of the hydrogel and a corresponding decrease in the swelling index. Other characterization techniques like Fourier Transform Infra-Red Spectroscopy, X-Ray Diffraction, ThermoGravimetry—Differential Scanning Calorimetry, and optical microscopy analysis were carried out to study physicochemical interactions, crystallinity, thermal, and surface properties of the optimized hydrogel, respectively. The in vitro drug release studies by United States Pharmacopeia dissolution basket model and ex vivo permeation studies using Franz diffusion cell with goat buccal skin were carried out for 6 h, in different media such as distilled water, phosphate buffer pH 6.8, and simulated salivary fluid.

中文翻译：

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柠檬酸包覆双载药双层水凝胶治疗口干综合征

本研究的目的是配制醋氯芬酸和伊曲康唑的双层水凝胶，然后用柠檬酸进行表面喷涂，以治疗 HIV 患者的炎症、口腔念珠菌病和口腔干燥症。水凝胶是通过化学交联方法制备的，使用聚乙烯醇作为聚合物，浓度分别为 3%、5%、7% 和 9% w/v，用于单个药物和组合双层。在每个水凝胶系统中，交联剂（戊二醛 1% v/v）和催化剂（浓盐酸 [HCl]、稀盐酸和乙酸）的用量优化为 0.1 mL。所需的物理特性。水凝胶接受了各种评估参数，如重量变化（0.054-0.300 g）、直径（9.5-12.5 mm）、厚度（2.5-4.0 mm）、药物含量 (2.5–2.8 mg/mL) 和肿胀研究。聚合物组成的增加导致水凝胶厚度和重量的显着增加以及溶胀指数的相应降低。其他表征技术，如傅里叶变换红外光谱、X 射线衍射、热重-差示扫描量热法和光学显微镜分析，分别用于研究优化水凝胶的物理化学相互作用、结晶度、热和表面特性。美国药典溶出篮模型的体外药物释放研究和 其他表征技术，如傅里叶变换红外光谱、X 射线衍射、热重-差示扫描量热法和光学显微镜分析，分别用于研究优化水凝胶的物理化学相互作用、结晶度、热和表面特性。美国药典溶出篮模型的体外药物释放研究和 其他表征技术，如傅里叶变换红外光谱、X 射线衍射、热重-差示扫描量热法和光学显微镜分析，分别用于研究优化水凝胶的物理化学相互作用、结晶度、热和表面特性。美国药典溶出篮模型的体外药物释放研究和使用 Franz 扩散池和山羊颊皮肤在不同介质中进行 6 小时的体外渗透研究，如蒸馏水、磷酸盐缓冲液 pH 6.8 和模拟唾液。