Abstract

Objective

To prospectively evaluate the efficacy of microwave ablation (MWA) for benign breast lesions (BBLs) ≥2 cm and explore the possible factors associated with the volume reduction rate (VRR) of ablated lesions.

Materials and methods

From November 2013 to December 2017, a total of 80 patients with 104 biopsy-proved BBLs larger than 2 cm in size underwent MWA. After the procedure, patients were followed up via physical and imaging examination consisting of contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI). Possible factors associated with 12-month VRR were assessed, including basic patient characteristics, index lesions and parameters of ablation technique.

Results

The mean tumor size was 2.6 ± 0.6 cm (ranging 2.0–6.3 cm). Of the 104 lesions, 70 were fibroadenomas, 27 adenosis and 7 fibrocystic changes. Post-procedure CEUS or contrast-enhanced MRI showed that all lesions were completely ablated. No immediate or delayed complications were observed. All patients were followed up for more than 12 months (median follow-up 12.5 months). After MWA, the ablated lesion volume decreased significantly by 12 months (p < 0.001), with a mean volume reduction of 80.2 ± 13.1%. Multiple linear regression analysis showed that location adjacent to areola (β = 7.5, 95%CI: 1.0–13.9, p = 0.025) and location adjacent to skin (β = −7.4, 95%CI: −12.7 to −13.9, p = 0.007) were independent factors respectively associated with the increased and decreased 12-month VRR.

Conclusion

For BBLs larger than 2 cm, US-guided MWA is a favorable treatment modality, with BBLs adjacent to the areola being associated with more significant 12-month VRR after MWA.

中文翻译：

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超声引导下微波消融后≥2 cm乳腺良性病变的体积缩小，至少随访12个月

摘要

客观的

为了前瞻性评估微波消融（MWA）对≥2 cm的乳腺良性病变（BBL）的疗效，并探讨与消融灶体积缩小率（VRR）相关的可能因素。

材料和方法

从2013年11月到2017年12月，共有80例行活检的BBL大于2 cm的患者接受了MWA检验，共104例。手术后，通过包括造影剂超声（CEUS）和磁共振成像（MRI）在内的身体和影像学检查对患者进行随访。评估了与12个月VRR相关的可能因素，包括患者的基本特征，指标病变和消融技术参数。

结果

平均肿瘤大小为2.6±0.6厘米（2.0-6.3厘米）。在104个病变中，有70个是纤维腺瘤，27个腺瘤和7个纤维囊变。术后CEUS或对比增强MRI显示所有病变均已完全消融。没有观察到立即或延迟的并发症。所有患者均接受了超过12个月的随访（中位随访12.5个月）。MWA后，消融的病变体积显着减少了12个月（p  <0.001），平均体积减少了80.2±13.1％。多元线性回归分析显示，邻近乳晕的位置（β  = 7.5，95％CI：1.0-13.9，p  = 0.025）和邻近皮肤的位置（β = -7.4，95％CI：-12.7至-13.9，p = 0.007）是分别与12个月VRR升高和降低相关的独立因素。

结论

对于大于2 cm的BBL，美国指导的MWA是一种有利的治疗方式，邻近乳晕的BBL与MWA后12个月的VRR显着相关。