Abstract

T cell immunoglobulin and mucin domain-containing molecule-3(Tim-3) has been found to play important roles in systemic lupus erythematosus (SLE), but whether sTim-3 is involved in the development of SLE remains unknown. In this study, we firstly observed an increased expression of plasma sTim-3 in SLE patients, especially active SLE patients. The plasma sTim-3 levels were positively correlated with anti-dsDNA, SLEDAI score, ESR, and urine albumin. The plasma sTim-3 levels were negatively correlated with C3 and C4. The area under the ROC curve (AUC) values indicated that the plasma sTim-3 level was significantly discriminative of early active SLE from stable SLE and HC with high sensitivity and specificity. The present results suggest that sTim-3 might serve as a potential biomarker for promising the disease activity of SLE.

摘要

已发现 T 细胞免疫球蛋白和含粘蛋白结构域的分子 3（Tim-3）在系统性红斑狼疮（SLE）中发挥重要作用，但 sTim-3 是否参与 SLE 的发展仍不清楚。在这项研究中，我们首先观察到 SLE 患者，尤其是活动性 SLE 患者血浆 sTim-3 的表达增加。血浆 sTim-3 水平与抗 dsDNA、SLEDAI 评分、ESR 和尿白蛋白呈正相关。血浆 sTim-3 水平与 C3 和 C4 呈负相关。ROC 曲线下面积 (AUC) 值表明，血浆 sTim-3 水平以高灵敏度和特异性显着区分早期活动性 SLE 与稳定 SLE 和 HC。目前的结果表明 sTim-3 可能作为潜在的生物标志物，用于预测 SLE 的疾病活动。