Animal models of invasive fungal infections have been developed and are applied in a huge number of different animal species for a number of research purposes, for example, the study of pathogenesis, defense mechanisms, and therapeutic strategies. From the different models, which in most cases are based on the same fungal species and often the same strain, as in spontaneous human infections, fundamental results and knowledge of the diagnosis, progression, prophylaxis, and therapy have been achieved. However, in all models, one should be critical with respect to mimicking the disease entity of humans, which is often the focus of the research. In many of the models for instance, the time course is different to the one of humans, and in others, the propensity for localization and containment in specific organs does not parallel the situation in humans. Nevertheless, many animal models of invasive mycoses have proven valuable in a number of research areas. With regard to new generations of anti-mycotic drugs, the models play an essential role in demonstrating antifungal activity, as well as in demonstrating the absence of toxic side effects, a critical step which cannot be accomplished by in vitro studies.

中文翻译：

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侵袭性真菌病动物模型

侵袭性真菌感染的动物模型已经开发出来，并应用于大量不同的动物物种，用于许多研究目的，例如研究发病机制、防御机制和治疗策略。从不同的模型中，在大多数情况下，这些模型基于相同的真菌种类并且通常是相同的菌株，如在自发性人类感染中，已经获得了诊断、进展、预防和治疗的基本结果和知识。然而，在所有模型中，在模仿人类疾病实体方面都应该是至关重要的，这通常是研究的重点。例如，在许多模型中，时间过程与人类不同，而在其他模型中，在特定器官中定位和遏制的倾向与人类的情况并不平行。尽管如此，许多侵入性真菌病的动物模型已在许多研究领域证明是有价值的。对于新一代抗真菌药物，这些模型在证明抗真菌活性以及证明没有毒副作用方面发挥着重要作用，这是体外研究无法完成的关键步骤。