Lutein-b-methoxy polyethylene glycol (Lutein-b-mPEG) encapsulated lutein nanoemulsion was prepared. First, mercapto-terminated mPEG (mPEG-SH) was prepared. Then, vinyl-terminated lutein was prepared by the esterification reaction of lutein and allyl chloroformate. Finally, Lutein-b-mPEG was synthesized by the thiol-ene reaction of the vinyl-terminated intermediate and mPEG-SH. Lutein-b-mPEG was self-assembled in water to form spherical micelles, and the unreacted lutein was directly loaded in the micelles. The synthesis of the block copolymer and loading of unreacted lutein are completed in one pot. The results of IR, ¹H NMR, GPC, and surface tension showed that the Lutein-b-mPEG was prepared. The TEM results showed that Lutein-b-mPEG loaded lutein self-assembled in water to form spherical micelles, and the average size is larger than that of Lutein-b-mPEG micelles. The chemical stability of lutein loaded by Lutein-b-mPEG micelles is greatly enhanced. Moreover, due to the water solubility and micellization of lutein, it is possible to greatly increase its bioavailability.

制备了叶黄素-b-甲氧基聚乙二醇（Lutein-b-mPEG）封装的叶黄素纳米乳液。首先，制备巯基封端的mPEG（mPEG-SH）。然后，通过叶黄素与氯甲酸烯丙酯的酯化反应制备乙烯基封端的叶黄素。最后，通过乙烯基封端的中间体和mPEG-SH的硫醇-烯反应合成叶黄素-b-mPEG。叶黄素-b-mPEG在水中自组装形成球形胶束，未反应的叶黄素直接负载在胶束中。嵌段共聚物的合成和未反应的叶黄素的加载在一锅中完成。IR的结果，¹1 H NMR，GPC和表面张力表明制备了叶黄素-b-mPEG。TEM结果表明，载有叶黄素-b-mPEG的叶黄素在水中自组装形成球形胶束，其平均粒径大于叶黄素-b-mPEG的胶束。叶黄素-b-mPEG胶束负载的叶黄素的化学稳定性大大提高。此外，由于叶黄素的水溶性和胶束化作用，可以大大提高其生物利用度。