ABSTRACT

Aim

To evaluate the occurrence of food allergy to walnuts and hazelnuts in atopic dermatitis patients.

Methods

The examination of specific IgE to molecular components with Multiplex ISAC testing was performed. The diagnosis of food allergy was confirmed in patients suffering from food reactions to walnuts/hazelnuts together with positive results of specific IgE to molecular components.

Results and conclusion

: Altogether 100 atopic dermatitis patients were examined – 48 men, 52 women, the average age 40.9 years. Hazelnuts allergy was confirmed in 25% of patients; these patients are majorly allergic to PR 10 protein, minorly to storage proteins. Walnut allergy was confirmed in 14% of patients; these patients are majorly allergic to storage proteins and to non-specific lipid transfer proteins. Sensitization to Bet v 1 homologues and profilins was associated with mild symptoms; nsLTPs and seed storage proteins were related to severe reactions.

中文翻译：

---

特应性皮炎患者对核桃和榛子的过敏以及对分子成分的敏感性分析

摘要

目的

评估特应性皮炎患者对核桃和榛子食物过敏的发生情况。

方法

用Multiple ISAC测试对分子组分的特异性IgE进行了检查。在对核桃/榛子有食物反应的患者中，对食物过敏的诊断得到了证实，并且对分子成分有特异性IgE的阳性结果。

结果与结论

：共检查了100例特应性皮炎患者-男性48例，女性52例，平均年龄40.9岁。在25％的患者中确认了榛子过敏；这些患者主要对PR 10蛋白过敏，次要对存储蛋白过敏。14％的患者确认了核桃过敏；这些患者主要对存储蛋白和非特异性脂质转移蛋白过敏。对Bet v 1同源物和profilins的敏化与轻度症状有关。nsLTP和种子贮藏蛋白与严重反应有关。