The intertwined processes of thrombosis and inflammation (termed “thrombo‐inflammation”) are significant drivers of cerebrovascular diseases, and as such, they represent prime targets for drug discovery programs focusing on treatment and management of cerebrovascular diseases. Most cerebrovascular events result from chronic systemic microcirculatory dysfunction due to underlying conditions, for example, hypertension, diabetes mellitus, coronary artery disease, dyslipidemia, and sickle cell disease. Immune cells especially neutrophils play a critical role in the onset and maintenance of neuroinflammatory responses in the microcirculation. Neutrophils have the ability to drive both inflammatory and anti‐inflammatory/pro‐resolution effects depending on the underlying vascular state (physiological vs. pathological). In this article, we highlight the pathophysiological role of neutrophils in stroke and discuss ongoing pharmacotherapeutic strategies that are focused on identifying potential therapeutic targets for enhancing neuroprotection, mitigating inflammatory pathways, and enabling resolution.

中文翻译：

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血栓炎症对脑微循环的影响

血栓形成和炎症（称为“血栓炎症”）的交织过程是脑血管疾病的重要驱动因素，因此，它们代表了专注于脑血管疾病治疗和管理的药物发现计划的主要目标。大多数脑血管事件是由潜在疾病引起的慢性全身性微循环功能障碍引起的，例如高血压、糖尿病、冠状动脉疾病、血脂异常和镰状细胞病。免疫细胞特别是中性粒细胞在微循环中神经炎症反应的发生和维持中起关键作用。中性粒细胞具有驱动炎症和抗炎/促消退作用的能力，具体取决于潜在的血管状态（生理与病理）。在这篇文章中，