The 3′-end processing of most pre-messenger RNAs (pre-mRNAs) involves RNA cleavage and polyadenylation and is coupled to transcription termination. In both yeast and human cells, pre-mRNA 3′-end cleavage is globally inhibited by DNA damage. Recently, further links between pre-mRNA 3′-end processing and the control of genome stability have been uncovered, as reviewed here. Upon DNA damage, various genes related to the DNA damage response (DDR) escape 3′-end processing inhibition or are regulated through alternative polyadenylation (APA). Conversely, various pre-mRNA 3′-end processing factors prevent genome instability and are found at sites of DNA damage. Finally, the reciprocal link between pre-mRNA 3′-end processing and genome stability control seems important because it is conserved in evolution and involved in disease development.

大多数前信使 RNA (pre-mRNA) 的 3' 端加工涉及 RNA 切割和多聚腺苷酸化，并与转录终止相关。在酵母和人类细胞中，前体 mRNA 3'-末端切割受到 DNA 损伤的全面抑制。最近，已发现前 mRNA 3'-末端加工与基因组稳定性控制之间的进一步联系，如本文所述。在 DNA 损伤时，与 DNA 损伤反应 (DDR) 相关的各种基因逃避 3' 端加工抑制或通过替代多聚腺苷酸化 (APA) 进行调节。相反，各种前 mRNA 3' 端加工因子可防止基因组不稳定，并在 DNA 损伤位点发现。最后，pre-mRNA 3'-末端加工和基因组稳定性控制之间的相互联系似乎很重要，因为它在进化中是保守的并参与疾病发展。