Bie Jia Jian Pill Combined with Bone Mesenchymal Stem Cells Regulates microRNA-140 to Suppress Hepatocellular Carcinoma Stem Cells.,International Journal of Stem Cells

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Bie Jia Jian Pill Combined with Bone Mesenchymal Stem Cells Regulates microRNA-140 to Suppress Hepatocellular Carcinoma Stem Cells.
International Journal of Stem Cells ( IF 2.3 ) Pub Date : 2021-02-28 , DOI: 10.15283/ijsc20157
Huang Jingjing _{1,

2} , Huang Hongna ₃ , Zhang Wenfu ₄ , Lv Jianlin ₄ , Huang Guochu ₁ , Lin Yuanjia ₁ , Chen Songlin ₅ , Hu Yueqiang _{3,

6}

Affiliation

Cancer stem cells (CSCs) with tumorigenic potential are reported as the crucial factors of hepatocellular carcinoma (HCC) recurrence and therapy resistance. Bone mesenchymal stem cells (BMSCs) are documented to play an important role in the protection of hepatocytes. Bie Jia Jian pill (BJJP), a Traditional Chinese Medicine, has been used to treat liver fibrosis and liver cancer. This study aimed to explore the potential role of combined use of BJJP with BMSCs in HCC cell lines.

中文翻译：

别家健丸联合骨间充质干细胞调控microRNA-140抑制肝癌干细胞

据报道，具有致瘤潜力的癌症干细胞 (CSC) 是肝细胞癌 (HCC) 复发和治疗抵抗的关键因素。骨间充质干细胞 (BMSCs) 被证明在保护肝细胞方面发挥重要作用。别家健丸（BJJP）是一种中药，已被用于治疗肝纤维化和肝癌。本研究旨在探讨联合使用 BJJP 与 BMSCs 在 HCC 细胞系中的潜在作用。

更新日期：2021-03-01

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