Ischemic stroke is one of the catastrophic neurological events that are being increasingly recognized among Coronavirus Disease (COVID)-19 patients. The recent studies have revealed about a possible connection among COVID-19, ischemic stroke, and excessive Neutrophil Extracellular Traps (NETs) formation. This paper establishes an overview of coronaviruses and NETs, NETs in pathogenesis of COVID-19 induced-ischemic stroke, and future directions using related recent literatures. NETs are normally functioned for a defense against pathogens, but in immoderate amount, they can trigger series of destructive events. Vasculopathy and neuroinflammation are the pathological mechanisms of NETs suggested to link COVID-19 and ischemic stroke. Based on newly discovered possible mechanisms, the potential clinical implications that could be applied consists of inhibition of NET formation, disrupting cholesterol synthesis, and interfering inflammatory pathway. A considerable number of scientific works are needed in order to complete the current understanding of the emerging relationship among COVID-19, NETs, and ischemic stroke. Although the exact mechanism is still unknown, these novel findings are a worthwhile contribution in defining future studies, suitable future frameworks, and therapeutic strategies.

中文翻译：

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冠状病毒疾病19相关性缺血性中风中的中性粒细胞胞外陷阱：神经科学的新途径。

缺血性中风是严重的神经系统事件之一，在冠状病毒病（COVID）-19患者中越来越多地被认识到。最近的研究表明，COVID-19，缺血性中风和过度嗜中性白细胞外细胞陷阱（NETs）形成之间可能存在联系。本文使用相关的最新文献建立了冠状病毒和NETs的概述，NETs在COVID-19诱导的缺血性中风的发病机理中的应用，以及未来的发展方向。NET通常具有防御病原体的功能，但数量过少会触发一系列破坏性事件。血管病和神经炎症是建议将COVID-19与缺血性中风联系起来的NETs的病理机制。根据新发现的可能机制，可能应用的潜在临床含义包括抑制NET的形成，破坏胆固醇的合成以及干扰炎症途径。为了完成对COVID-19，NET和缺血性卒中之间新出现的关系的最新了解，需要进行大量的科学工作。尽管确切的机制仍是未知的，但是这些新颖的发现对于定义未来的研究，合适的未来框架和治疗策略是值得的。