Background: Biscoumarin scaffolds are known for their promising pharmacological properties. These compounds have not been studied for their activity against tuberculosis strains.

Objective: Unveil the antitubercular properties of biscoumarin scaffolds.

Methods: Biscoumarin derivatives (3a-3l) were synthesized using lemon juice as a catalyst and were investigated for their in-vitro anti-tubercular activity against the H₃₇R_v strain of Mycobacterium tuberculosis using Microplate Alamar Blue Assay Method (MABA). Their binding interaction was investigated by Molecular Docking Studies using InhA with PDB-ID: 2NSD as target receptors in the Hsub>37

中文翻译：

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通过生物学评估和对接研究揭示双香豆素的抗结核特性

背景：双香豆素支架因其有希望的药理特性而闻名。尚未研究这些化合物对结核菌株的活性。

目的：揭示双香豆素支架的抗结核特性。

方法：以柠檬汁为催化剂合成双香豆素衍生物（3a-3l），并使用微孔板阿拉法蓝测定法（MABA）研究其对结核分枝杆菌H ₃₇ R _v菌株的体外抗结核活性。通过分子对接研究，使用InhA和PDB-ID：2NSD作为Hsub> 37中的靶受体，研究了它们的结合相互作用。