Background We examined the associations between the 6-year incidence of age-related macular degeneration (AMD) and vision-related quality of life (VRQoL), and the contribution of presenting visual acuity (VA), in an Asian population. Methods Fundus images from the Singapore Chinese Eye Study, a population-based cohort study (baseline: 2009–2011; follow-up: 2015–2017), were graded using a modified Wisconsin age-related maculopathy grading system. Incident AMD was defined as no baseline AMD in both eyes and early/late AMD in the worse eye at follow-up. Presenting VA was assessed using the logarithm of the minimum angle of resolution chart at 4 m under standard lighting conditions with habitual correction. Multiple linear regression models determined the associations between AMD incidence with changes in the Rasch-transformed scores of the Reading, Mobility and Emotional VRQoL domains of the 32-item Impact of Visual Impairment (IVI-32) questionnaire, adjusted for traditional confounders. The contribution of presenting VA to changes in VRQoL was also estimated. Results Of the 2251 participants without AMD at baseline (mean age (SD): 57.7 (9) years, 51.4% women), 101 (4.5%) and 11 (0.5%) developed incident early and late AMD at follow-up, respectively. Incident late AMD was associated with significant 30.3%, 32.5% and 30.9% decrements in Reading, Mobility and Emotional IVI scores, respectively. The contribution of presenting VA ranged between 1.62% and 4.35% of the observed decrements. No significant associations were noted with incident early AMD. Conclusion Incident late AMD had a substantial impact on all aspects of VRQoL, with presenting VA contributing only minimally to this longitudinal relationship. Data are available upon reasonable request. Due to Singapore’s strict data sharing law, any data requests will be considered on a case-by-case basis.

中文翻译：

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事件性年龄相关性黄斑变性和相关视力丧失对视力相关生活质量的影响

背景 我们检查了亚洲人群中年龄相关性黄斑变性 (AMD) 和视力相关生活质量 (VRQoL) 的 6 年发病率之间的关联，以及呈现视力 (VA) 的贡献。方法 新加坡华人眼科研究是一项基于人群的队列研究（基线：2009-2011；随访：2015-2017），使用改良的威斯康星州年龄相关性黄斑病变分级系统对眼底图像进行分级。事件 AMD 被定义为在随访时双眼中没有基线 AMD 和早期/晚期 AMD 中较差的眼睛。在标准照明条件下使用 4 m 处的最小分辨率图表角度的对数评估呈现 VA，并进行习惯性校正。多元线性回归模型确定了 AMD 发病率与阅读的 Rasch 转换分数变化之间的关联，32 项视力障碍影响 (IVI-32) 问卷的流动性和情绪 VRQoL 领域，针对传统混杂因素进行了调整。还估计了呈现 VA 对 VRQoL 变化的贡献。结果 在基线时没有 AMD 的 2251 名参与者中（平均年龄 (SD)：57.7 (9) 岁，51.4% 女性），分别有 101 (4.5%) 和 11 (0.5%) 人在随访中出现早期和晚期 AMD . 事件晚期 AMD 与阅读、活动能力和情绪 IVI 分数分别显着下降 30.3%、32.5% 和 30.9% 相关。呈现 VA 的贡献范围在观察到的减量的 1.62% 和 4.35% 之间。未发现与早期 AMD 事件有显着关联。结论 晚期 AMD 事件对 VRQoL 的各个方面都有重大影响，呈现 VA 对这种纵向关系的贡献很小。可根据合理要求提供数据。由于新加坡严格的数据共享法，任何数据请求都将根据具体情况予以考虑。