Contagious bovine pleuropneumonia (CBPP) is an infectious and highly contagious respiratory disease of cattle and water buffalo, which is caused by the Mycoplasma mycoides subspecies mycoides small colony. It induces significant economic losses and leads to a serious food security problem, negatively influencing peoples' livelihoods in affected countries. The disease has been reported in different parts of Ethiopia with prevalence ranging from 1.78 to 96%. However, there is not enough epidemiological information about CBPP in the northwestern part of the country, particularly in North Gondar Administrative Zone. This cross-sectional study, therefore, was conducted in four selected districts (Metema, Alefa, Quara, and Dembia) of North Gondar Administrative Zone to detect the incursion and estimate the seroprevalence of CBPP and to identify the potential predisposing factors associated with the spread and occurrence of CBPP in the area. A total of 751 serum samples were collected from 41 herds (villages) having no history of CBPP vaccination. Information like age, sex, breed, herd size, and management were collected during blood sample collection. Data related to agro-climatic zone, trade trekking route from or through CBPP endemic/epidemic zone, transhumance grazing route, vehicle route, and bordering with CBPP epidemic/endemic zone were obtained from district agricultural offices. The serum was screened for CBPP using competitive enzyme-linked immunosorbent assay (c-ELISA) test. The animal level and herd level apparent seroprevalences were 12.92% (95% CI: 10.70–15.52) and 65.85% (95% CI: 49.57–79.10), respectively. The true animal level and herd level prevalences were estimated at 20.13% (95% CI: 16.64–24.21) and 65.22% (95% CI: 48.64–78.72%), respectively. At the animal level, trekking route from or through CBPP endemic/epidemic zone to the study area [OR = 4.77 (95% CI: 1.92–11.84) compared to without trekking route] was identified as the most important risk factor for CBPP spread and seropositivity. In general, epidemiological evidence of the present study indicates that CBPP is a prevalent disease, and animal trekking is an important risk factor for spread of the disease in the study area. This needs due attention from the government and other concerned bodies for its prevention and control to mitigate its economic impact.

传染性牛胸膜肺炎（CBPP）是牛和水牛的一种传染性、高度接触性呼吸道疾病，由牛传染性肺炎引起。丝状支原体亚种蕈状菌小殖民地。它造成重大经济损失，导致严重的粮食安全问题，给受影响国家的人民生计带来负面影响。埃塞俄比亚不同地区均有报道该病，患病率在 1.78% 至 96% 之间。然而，该国西北部地区，特别是北贡德尔行政区，没有足够的 CBPP 流行病学信息。因此，这项横断面研究是在北贡德尔行政区的四个选定地区（梅特马、阿莱法、夸拉和登比亚）进行的，以检测 CBPP 的入侵并估计 CBPP 的血清阳性率，并确定与传播相关的潜在诱发因素以及该地区 CBPP 的发生情况。共采集41个无CBPP疫苗接种史的牛群（村）血清样本751份。在血样采集过程中收集了年龄、性别、品种、牛群规模和管理等信息。农业气候区、往返 CBPP 流行区/流行区的贸易徒步路线、游牧放牧路线、车辆路线以及与 CBPP 流行区/流行区接壤的相关数据均从区农业办公室获得。使用竞争性酶联免疫吸附测定 (c-ELISA) 测试筛选血清中的 CBPP。动物水平和畜群水平的表观血清阳性率分别为 12.92% (95% CI: 10.70–15.52) 和 65.85% (95% CI: 49.57–79.10)。真实动物水平和群体水平患病率估计分别为 20.13% (95% CI: 16.64–24.21) 和 65.22% (95% CI: 48.64–78.72%)。在动物水平上，从或通过 CBPP 流行区/流行区到研究区域的徒步路线 [OR = 4.77 (95% CI: 1.92–11.84) 与没有徒步路线相比] 被确定为 CBPP 传播的最重要的风险因素，血清阳性。总的来说，本研究的流行病学证据表明 CBPP 是一种流行疾病，动物徒步旅行是该疾病在研究地区传播的重要危险因素。这需要政府和其他有关机构的足够重视，进行预防和控制，以减轻其经济影响。