Ajuba has been found to be mutated or aberrantly regulated in several human cancers and plays important roles in cancer progression via different signaling pathways. However, little is known about the role of Ajuba in hepatocellular carcinoma (HCC). Here, we found an upregulation of Ajuba expression in HCC tissues compared with normal liver tissues, while a poor prognosis was observed in HCC patients with high Ajuba expression. Knockout of Ajuba in HCC cells inhibited cell growth in vitro and in vivo, suppressed cell migration, and enhanced the cell apoptosis under stress. Moreover, re-expression of Ajuba in Ajuba-deficient cells could restore the phenotype of Ajuba-deficient cells. In conclusion, these results indicate that Ajuba is upregulated in HCC and promotes cell growth and migration of HCC cells, suggesting that Ajuba could possibly be a new target for HCC diagnosis and treatment.
Cytogenet Genome Res

中文翻译：

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阿朱巴的敲除减弱了肝癌细胞的生长和迁移。

已经发现阿朱巴在几种人类癌症中被突变或异常调节，并且通过不同的信号传导途径在癌症进展中起重要作用。但是，关于Ajuba在肝细胞癌（HCC）中的作用知之甚少。在这里，我们发现与正常肝组织相比，HCC组织中Ajuba表达上调，而在具有高Ajuba表达的HCC患者中观察到不良预后。敲除Ajuba在HCC细胞中可在体外和体内抑制细胞生长，抑制细胞迁移，并增强应激条件下的细胞凋亡。此外，Ajuba缺陷细胞中Ajuba的重新表达可以恢复Ajuba缺陷细胞的表型。总之，这些结果表明Ajuba在HCC中被上调，并促进HCC细胞的生长和迁移，
细胞遗传学基因组研究