We investigated the efficacy of donepezil for mild cognitive impairment in Parkinson’s disease (PD-MCI). This was a prospective, non-randomized, open-label, two-arm study. Eighty PD-MCI patients were assigned to either a treatment or control group. The treatment group received donepezil for 48 weeks. The primary outcome measures were the Korean version of Mini-Mental State Exam and Montreal Cognitive Assessment scores. Secondary outcome measures were the Clinical Dementia Rating, Unified Parkinson’s Disease Rating Scale part III, Clinical Global Impression scores. Progression of dementia was assessed at 48-week. Comprehensive neuropsychological tests and electroencephalography (EEG) were performed at baseline and after 48 weeks. The spectral power ratio of the theta to beta2 band (TB2R) in the electroencephalogram was analyzed. There was no significant difference in the primary and secondary outcome measures between the two groups. However, the treatment group showed a significant decrease in TB2R at bilateral frontotemporoparietal channels compared to the control group. Although we could not demonstrate improvements in the cognitive functions, donepezil treatment had a modulatory effect on the EEG in PD-MCI patients. EEG might be a sensitive biomarker for detecting changes in PD-MCI after donepezil treatment.

我们研究了多奈哌齐对帕金森病 (PD-MCI) 轻度认知障碍的疗效。这是一项前瞻性、非随机、开放标签、双臂研究。80 名 PD-MCI 患者被分配到治疗组或对照组。治疗组接受多奈哌齐治疗48周。主要结果测量是韩文版的简易精神状态考试和蒙特利尔认知评估分数。次要结果测量是临床痴呆评定、统一帕金森病评定量表第 III 部分、临床总体印象评分。在 48 周时评估痴呆的进展。在基线和 48 周后进行了全面的神经心理学测试和脑电图 (EEG)。分析了脑电图中 theta 与 beta2 波段 (TB2R) 的频谱功率比。两组之间的主要和次要结果指标没有显着差异。然而，与对照组相比，治疗组显示双侧额颞顶通道的 TB2R 显着降低。虽然我们无法证明认知功能的改善，但多奈哌齐治疗对 PD-MCI 患者的脑电图有调节作用。EEG 可能是检测多奈哌齐治疗后 PD-MCI 变化的敏感生物标志物。多奈哌齐治疗对 PD-MCI 患者的脑电图有调节作用。EEG 可能是检测多奈哌齐治疗后 PD-MCI 变化的敏感生物标志物。多奈哌齐治疗对 PD-MCI 患者的脑电图有调节作用。EEG 可能是检测多奈哌齐治疗后 PD-MCI 变化的敏感生物标志物。