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Review of biosensing with whispering-gallery mode lasers
Light: Science & Applications ( IF 19.4 ) Pub Date : 2021-02-26 , DOI: 10.1038/s41377-021-00471-3
Nikita Toropov , Gema Cabello , Mariana P. Serrano , Rithvik R. Gutha , Matías Rafti , Frank Vollmer

Lasers are the pillars of modern optics and sensing. Microlasers based on whispering-gallery modes (WGMs) are miniature in size and have excellent lasing characteristics suitable for biosensing. WGM lasers have been used for label-free detection of single virus particles, detection of molecular electrostatic changes at biointerfaces, and barcode-type live-cell tagging and tracking. The most recent advances in biosensing with WGM microlasers are described in this review. We cover the basic concepts of WGM resonators, the integration of gain media into various active WGM sensors and devices, and the cutting-edge advances in photonic devices for micro- and nanoprobing of biological samples that can be integrated with WGM lasers.



中文翻译:

耳语画廊模式激光的生物传感综述

激光是现代光学和传感技术的基础。基于耳语画廊模式(WGM)的微激光体积很小,并且具有适合生物传感的出色激光特性。WGM激光器已用于无标记的单个病毒颗粒检测,生物界面分子静电变化检测以及条形码型活细胞标记和跟踪。WGM微激光在生物传感方面的最新进展已在本综述中进行了描述。我们将介绍WGM谐振器的基本概念,将增益介质集成到各种有源WGM传感器和设备中,以及可与WGM激光器集成的用于对生物样品进行微米和纳米探测的光子设备的最新进展。

更新日期:2021-02-26
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