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Delta Neutrophil Index as a Diagnostic Marker of Neonatal Sepsis
Journal of Pediatric Infectious Diseases ( IF 0.3 ) Pub Date : 2021-02-25 , DOI: 10.1055/s-0041-1726118
Nuriye Asli Melekoglu 1 , Seyma Yasar 2 , Mehmet Keskin 3
Affiliation  

Objective Sepsis diagnosis is challenging due to nonspecific symptomatology in newborns. Timely diagnosis is essential for reducing sepsis-related morbidity and mortality. This study was performed to determine the diagnostic value of the delta neutrophil index (DNI) for detection of neonatal sepsis and to compare its efficacy with other conventional markers.

Methods This study was conducted at a tertiary hospital in newborns with confirmed sepsis (n = 59), suspected sepsis (n = 46), and in age- and weight-matched controls (n = 49). DNI, white blood cell count, C-reactive protein (CRP) level, and platelet measurements were determined, and blood cultures were performed at the onset of symptoms.

Results The mean DNI was significantly higher in confirmed and clinical sepsis groups compared with the control group. (6.9 ± 9.3, 1.9 ± 2.1, and 0.4 ± 0.5, respectively, p < 0.001). ROC curve analysis also showed that the combination of DNI and CRP had the highest sensitivity (86%), specificity (100%), and positive predictive value (100%) for predicting neonatal sepsis. DNI values were significantly higher in nonsurvivors (p < 0.05).

Conclusion DNI could be used as a reliable diagnostic marker for neonatal sepsis, and high DNI could predict sepsis development and unfavorable outcomes. The diagnostic capability of DNI may be increased by assessing CRP measurements simultaneously.



中文翻译:

Delta Neutrophil指数作为新生儿败血症的诊断标志

 由于新生儿的非特异性症状,客观的败血症诊断具有挑战性。及时诊断对于降低败血症相关的发病率和死亡率至关重要。进行这项研究是为了确定δ中性粒细胞指数(DNI)对新生儿败血症的诊断价值,并将其与其他常规标志物的疗效进行比较。

方法 该研究在三级医院进行,新生儿确诊为败血症(n  = 59),疑似败血症(n  = 46),年龄和体重相符的对照组(n  = 49)。测定DNI,白细胞计数,C反应蛋白(CRP)水平和血小板测量,并在症状发作时进行血液培养。

结果 确诊组和临床败血症组的平均DNI显着高于对照组。(分别为6.9±9.3、1.9±2.1和0.4±0.5,p  <0.001)。ROC曲线分析还显示,DNI和CRP的组合对预测新生儿败血症具有最高的敏感性(86%),特异性(100%)和阳性预测值(100%)。非存活者的DNI值显着更高(p  <0.05)。

结论 DNI可以作为新生儿败血症的可靠诊断指标,高DNI可以预测败血症的发展和不良的预后。通过同时评估CRP测量值,可以提高DNI的诊断能力。

更新日期:2021-02-26
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