Flow cytometry detection of CD138 expression continuum between monotypic B and plasma cells is associated with both high IgM peak levels and MYD88 mutation and contributes to diagnosis of Waldenström macroglobulinemia,Cytometry Part B: Clinical Cytometry

当前位置： X-MOL 学术 › Cytom. Part B Clin. Cytom. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Flow cytometry detection of CD138 expression continuum between monotypic B and plasma cells is associated with both high IgM peak levels and MYD88 mutation and contributes to diagnosis of Waldenström macroglobulinemia
Cytometry Part B: Clinical Cytometry ( IF 3.4 ) Pub Date : 2021-02-25 , DOI: 10.1002/cyto.b.21995
Mylene Gayet ₁ , Vincent Leymarie ₁ , Paco Derouault ₂ , Estelle Guérin _{1,

3} , Julien Vaidié ₄ , Virginie Pascal _{3,

5} , Mélanie Boulin ₁ , Nataliya Dmytruk ₄ , Jasmine Chauzeix _{1,

3} , Franck Trimoreau ₁ , Nathalie Gachard _{1,

3} , Jean Feuillard _{1,

3} , David Rizzo _{1,

3}

Affiliation

Differential diagnosis of Waldenström macroglobulinemia (WM) with other indolent B-cell malignancies is still a challenge. Here, we propose an original and simple analysis of routine flow cytometry (FCM) unraveling the characteristic ongoing plasma cell (PC) differentiation of WM tumor B-cells.

中文翻译：

流式细胞术检测单型 B 和浆细胞之间的 CD138 连续表达与高 IgM 峰值水平和 MYD88 突变相关，有助于诊断 Waldenström 巨球蛋白血症

Waldenström 巨球蛋白血症 (WM) 与其他惰性 B 细胞恶性肿瘤的鉴别诊断仍然是一个挑战。在这里，我们提出了对常规流式细胞术 (FCM) 的原始而简单的分析，以揭示 WM 肿瘤 B 细胞的特征性正在进行的浆细胞 (PC) 分化。

更新日期：2021-02-25

点击分享查看原文

点击收藏

阅读更多本刊最新论文

全部期刊列表>>