Optical Materials ( IF 3.9 ) Pub Date : 2021-02-25 , DOI: 10.1016/j.optmat.2021.110941 Jiantao Zhu , Huiyuan Chu , Jiwei Shen , Chaozhan Wang , Yinmao Wei
Doxorubicin (DOX) represents an anthracycline-based antitumor and antibiotic medication. The determination of DOX in body fluids is of significance for treatment and individual dosage optimization. In this paper, a ratiometric fluorescence probe for the detection of DOX is established using plum-based carbon quantum dots (PCQDs) prepared form plum as precursors via facile bottom-up method. The prepared PCQDs show green fluorescence with excitation/emission wavelength at 388/491 nm. DOX can be measured by the fluorescence intensity ratio at 591 nm and 491 nm, and the detection concentration range is from 1 to 30 μM with a limit detection of 0.12 μM (3σ/k). The method shows good anti-interference and is successfully applied to the determination of DOX in human urine and human serum samples with satisfactory recoveries (92.61–116.64%), indicating that this method can be used as an alternative in the detection of DOX in clinic.
中文翻译:
绿色的李子碳点制备物,作为用于检测阿霉素的比例荧光探针
阿霉素(DOX)代表基于蒽环类的抗肿瘤和抗生素药物。体液中DOX的测定对于治疗和优化个体剂量具有重要意义。在本文中,用于检测DOX的比率荧光探针,使用既定的梅系碳量子点(PCQDs)制备的形式梅通过简便的自下而上的方法作为前体。制备的PCQD显示绿色荧光,激发/发射波长为388/491 nm。可以通过591 nm和491 nm处的荧光强度比来测量DOX,检测浓度范围为1至30μM,极限检测为0.12μM(3σ/ k)。该方法具有良好的抗干扰性,已成功用于人尿和人血清样品中DOX的测定,回收率令人满意(92.61–116.64%),表明该方法可作为临床中检测DOX的替代方法。