The emergence of COVID-19 pandemic has severely affected human health and world economies. According to WHO guidelines, continuous use of face mask is mandatory for personal protection for restricting the spread of bacteria and virus. Here, we report a 3-ply cotton-PLA-cotton layered biodegradable face-mask containing encapsulated phytochemicals in the inner-filtration layer. The nano-fibrous PLA filtration layer was fabricated using needleless electrospinning of PLA & phytochemical-based herbal-extracts. This 3-layred face mask exhibits enhanced air permeability with a differential pressure of 35.78 Pa/cm² and superior bacterial filtration efficiency of 97.9% compared to conventional face masks. Close-packed mesh structure of the nano-fibrous mat results in effective adsorption of particulate matter, aerosol particles, and bacterial targets deep inside the filtration layer. The outer hydrophobic layer of mask exhibited effective blood splash resistance up to a distance of 30 cm, ensuring its utilization for medical practices. Computational analysis of constituent phytochemicals using the LibDock algorithm predicted inhibitory activity of chemicals against the protein structured bacterial sites. The computational analysis projected superior performance of phytochemicals considering the presence of stearic acid, oleic acid, linoleic acid, and Arachidic acid exhibiting structural complementarity to inhibit targeted bacterial interface. Natural cotton fibers and PLA bio-polymer demonstrated promising biodegradable characteristics in the presence of in-house cow-dung based biodegradation slurry. Addition of jaggery to the slurry elevated the biodegradation performance, resulting in increment of change of weight from 07% to 12%. The improved performance was attributed to the increased sucrose content in biodegradation slurry, elevating the bacterial growth in the slurry. An innovative face mask has shown promising results for utilization in day-to-day life and medical frontline workers, considering the post-pandemic environmental impacts.

COVID-19 大流行的出现严重影响了人类健康 和世界经济。 根据世界卫生组织的指导方针，为了限制细菌和病毒的传播，必须持续使用口罩来保护个人。在这里， 我们报告 了一种 3 层棉-PLA-棉分层可生物降解口罩，其内部过滤层中含有封装的植物化学物质。纳米纤维 PLA 过滤层是使用 PLA 和基于植物化学的草药提取物的无针静电纺丝制成的。这种 3 层面罩具有增强的透气性，压差为 35.78 Pa/cm ²与传统口罩相比，细菌过滤效率高达 97.9%。纳米纤维垫的密排网状结构可有效吸附过滤层深处的颗粒物、气溶胶颗粒和细菌目标。口罩的疏水外层在30厘米的距离内表现出有效的抗血液飞溅能力，确保了其在医疗实践中的应用。使用 LibDock 算法对组成植物化学物质的计算分析预测了化学物质对蛋白质结构细菌位点的抑制活性。考虑到硬脂酸、油酸、亚油酸和花生酸的存在表现出结构互补性以抑制目标细菌界面，计算分析预测了植物化学物质的优越性能。天然棉纤维和 PLA 生物聚合物在内部牛粪基生物降解浆料存在的情况下表现出良好的生物降解特性。向浆液中添加粗糖提高了生物降解性能，导致重量变化从 07% 增加到 12%。性能的提高归因于生物降解浆液中蔗糖含量的增加，从而促进了浆液中的细菌生长。考虑到大流行后的环境影响，一种创新的面罩在日常生活和医疗一线工作者中显示出可喜的效果。导致重量变化从 07% 增加到 12%。性能的提高归因于生物降解浆液中蔗糖含量的增加，从而促进了浆液中的细菌生长。考虑到大流行后的环境影响，一种创新的面罩在日常生活和医疗一线工作者中显示出可喜的效果。导致重量变化从 07% 增加到 12%。性能的提高归因于生物降解浆液中蔗糖含量的增加，从而促进了浆液中的细菌生长。考虑到大流行后的环境影响，一种创新的面罩在日常生活和医疗一线工作者中显示出可喜的效果。