Introduction

A recent study showed hypoactivity in the beta/gamma band in female suicide ideators and suicide attempters diagnosed with depression, relative to a low-risk group. The current study aimed to conceptually replicate these results.

Methods

In the iSPOT-D sub-sample (n = 402), suicide ideators and low-risk individuals were identified. Confining analyses to females only, differences between low-risk individuals and suicide ideators were tested for using the electroencephalogram (EEG) frequency bands SMR (Sensori-Motor-Rhythm; 12−15 Hz), beta (14.5−30 Hz), beta I (14.5−20 Hz), beta II (20−25 Hz), beta III (25−30 Hz), gamma I (31−49 Hz) using LORETA-software.

Results

None of the tested frequency bands showed to be significantly different between suicide ideators and low-risk individuals.

Conclusions

The current study could not conceptually replicate the earlier published results. Several reasons could explain this non-replication, among which possible electromyographic (EMG) contamination in the beta/gamma band in the original study.

Trial Registration

ClinicalTrials.gov identifier: NCT00693849.

URL: http://clinicaltrials.gov/ct2/show/NCT00693849.

中文翻译：

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女性重度抑郁症患者自杀行为的脑电图特征？不可复制

介绍

最近的一项研究显示，女性自杀意念者和被诊断患有抑郁症的自杀未遂者的 β/γ 波段活动不足，相对于低风险群体。目前的研究旨在从概念上复制这些结果。

方法

在 iSPOT-D 子样本 (n = 402) 中，确定了自杀意念者和低风险个体。仅对女性进行分析，使用脑电图 (EEG) 频段 SMR（Sensori-Motor-Rhythm；12-15 Hz）、β（14.5-30 Hz）、β I 测试低风险个体和自杀意念者之间的差异（14.5−20 Hz）、beta II (20−25 Hz)、beta III (25−30 Hz)、gamma I (31−49 Hz) 使用 LORETA 软件。

结果

没有一个测试频段显示自杀意念者和低风险个体之间存在显着差异。

结论

目前的研究无法在概念上复制早期发表的结果。有几个原因可以解释这种非复制，其中可能是原始研究中 β/γ 波段中的肌电图 (EMG) 污染。

试用注册

ClinicalTrials.gov 标识符：NCT00693849。

网址：http://clinicaltrials.gov/ct2/show/NCT00693849。