当前位置: X-MOL 学术Psychopharmacology › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The acute effects of alcohol on state rumination in the laboratory
Psychopharmacology ( IF 3.4 ) Pub Date : 2021-02-26 , DOI: 10.1007/s00213-021-05802-1
O Merve Mollaahmetoglu 1 , Edward Palmer 1 , Emily Maschauer 1 , Melissa C Nolan 1 , Tobias Stevens 1 , Molly Carlyle 2 , Lorna Hardy 1 , Edward R Watkins 3 , Celia J A Morgan 1
Affiliation  

Rationale

Rumination is a repetitive, negative, self-focused thinking style associated with various forms of psychopathology. Recent studies suggest that rumination increases craving for alcohol and predicts harmful drinking and alcohol-related problems. However, the acute effects of alcohol on rumination have not been previously studied. It is proposed that alcohol may reduce ruminative thinking through decreasing negative mood.

Objectives

In the present study, we aimed to test the previously unexplored effects of acute alcohol consumption on rumination in a hazardous drinking population.

Methods

We conducted a randomised placebo-controlled laboratory study to examine the effect of low (0.4 g kg−1) and high doses (0.8 g kg−1) of alcohol on state rumination compared to placebo. Participants completed a rumination induction task prior to receiving drinks. We then measured state rumination and mood at repeated time points; 30 min, 60 min and 90 min post-drinks consumption.

Results

We found a significant decrease in state rumination in the low-dose alcohol group compared to placebo at 30 min post-alcohol consumption, but no difference was observed between the high-dose alcohol and placebo groups. Mediation analysis provided evidence for an indirect effect of alcohol on state rumination through concurrent changes in negative mood.

Conclusions

These findings suggest that acute alcohol consumption can regulate negative mood and concurrently rumination, providing preliminary evidence for the role of rumination in alcohol use disorders. Rumination may be a treatment target in alcohol use disorders.



中文翻译:

酒精对实验室状态反刍的急性影响

基本原理

反刍是一种重复的、消极的、以自我为中心的思维方式,与各种形式的精神病理学有关。最近的研究表明,反刍会增加对酒精的渴望,并预示有害的饮酒和与酒精有关的问题。然而,以前没有研究过酒精对反刍的急性影响。有人提出,酒精可以通过减少消极情绪来减少反刍思维。

目标

在本研究中,我们旨在测试先前未探索的急性饮酒对危险饮酒人群中反刍的影响。

方法

我们进行了一项随机安慰剂对照实验室研究,以检查与安慰剂相比,低(0.4 g kg -1)和高剂量(0.8 g kg -1)酒精对状态反刍的影响。参与者在接受饮料之前完成了反刍诱导任务。然后我们在重复的时间点测量状态反刍和情绪;饮酒后 30 分钟、60 分钟和 90 分钟。

结果

我们发现,在饮酒后 30 分钟,与安慰剂相比,低剂量酒精组的状态反刍显着减少,但在高剂量酒精组和安慰剂组之间没有观察到差异。中介分析提供了证据,证明酒精通过同时发生的消极情绪变化对状态反刍产生间接影响。

结论

这些发现表明,急性饮酒可以调节消极情绪并同时调节反刍,为反刍在酒精使用障碍中的作用提供了初步证据。反刍可能是酒精使用障碍的治疗目标。

更新日期:2021-02-26
down
wechat
bug