Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis,Nanoscale

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Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis
Nanoscale ( IF 6.7 ) Pub Date : 2021-2-20 , DOI: 10.1039/d0nr08887k
Weiwei Zhao _{1,

2,

3,

4,

5} , Hua Wang _{3,

4,

5,

6,

7} , Haimang Wang _{1,

2,

3,

4,

5} , Ying Han _{1,

2,

3,

4,

5} , Zhibo Zheng _{5,

8,

9,

10,

11} , Xudong Liu _{5,

9,

10,

11,

12} , Bin Feng _{5,

9,

10,

11,

13} , Hongyu Zhang _{1,

2,

3,

4,

5}

Affiliation

Visible light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement were constructed by supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles (bMSNs-AZO) and β-cyclodextrin-modified poly(2-methacryloyloxyethyl phosphorylcholine) (CD-PMPC). Visible light could effectively trigger azobenzene isomerization and thus induce drug release after passing through the dermal tissue. Additionally, the hydration layer formed by CD-PMPC on the surface of the nanoparticles played an important role in lubrication enhancement, which was beneficial for the treatment of osteoarthritis.

中文翻译：

光响应性双功能可生物降解的介孔二氧化硅纳米颗粒，具有药物输送和润滑作用，可用于治疗骨关节炎

通过偶氮苯改性的介孔二氧化硅纳米粒子（bMSNs-AZO）和β-环糊精改性的聚（2-甲基丙烯酰氧基乙基磷酰胆碱）（CD- PMPC）。可见光可以有效触发偶氮苯异构化，从而在通过真皮组织后诱导药物释放。另外，由CD-PMPC在纳米颗粒表面上形成的水合层在润滑增强中起着重要作用，这对于治疗骨关节炎是有益的。

更新日期：2021-02-25

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