Frullania is one of the largest and taxonomically most complex genus of leafy liverworts. Current morphology-based estimates of Frullania diversity are close to 400 species; however, species level-classification of Frullania has been regarded notoriously difficult and subject to many studies. The liverworts classified in this genus have been studied using morphological evidence and molecular markers but also in terms of secondary metabolite composition. Up to now 98 Frullania species have been chemically investigated. As a result, it is known that Frullania species are characterized by a remarkable chemical diversity. The most characteristic compounds present in this liverwort genus are sesquiterpene lactones with eudesamnolides as the most diverse group, and aromatic compounds belonging to bibenzyls. In this review paper we report the distribution of secondary metabolites in all chemically investigated Frullania species and discuss some aspects concerning the division of this genus into chemotypes.

Frullania是叶形艾蒿的最大和分类学上最复杂的属之一。目前基于形态学的Frullania多样性估计值接近400种。然而，众所周知，对Frullania进行物种级别分类非常困难，并且需要进行许多研究。已使用形态学证据和分子标记物以及次生代谢产物组成研究了归类于该属的艾蒿。到目前为止，已经对98种Frullania物种进行了化学研究。结果，人们知道Frullania物种的特点是化学物质的多样性。存在于该地蒿属中的最具特征性的化合物是倍半萜内酯，其中以desdesamnolides为最多样化的基团，以及属于联苄基的芳香族化合物。在这篇综述文章中，我们报告了次生代谢物在所有化学调查的Frullania物种中的分布，并讨论了有关将该属划分为化学型的某些方面。