A new sesquiterpenoid, chaenomelesterpenoid A (1), and a new norisoprenoid, chaenomelesterpenoid B (2), were isolated from the fruits of Chaenomeles sinensis (Thouin) Koehne. Their structures were determined by NMR spectroscopy and MS. In addition, the protective effects of the compounds were tested against corticosterone-induced damage in PC-12 cells using real-time cellular analysis (RTCA). Compounds 1 and 2 significantly improved cell viability and corticosterone-induced damage in PC-12 cells with EC₅₀ values of 15.7 and 12.6 µM, respectively.

中文翻译：

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两个新的萜类化合物从的水果木瓜（安帕图安）海棠

从Chaenomeles sinensis（Thouin）Koehne的果实中分离出一种新的倍半萜类，变态的类蛋黄素A（1）和一个新的类异戊二烯类的变态的类脂B（2）。它们的结构通过NMR光谱和MS确定。此外，使用实时细胞分析（RTCA）测试了化合物对PC-12细胞中皮质酮诱导的损伤的保护作用。化合物1和2分别以15.7和12.6 µM的EC ₅₀值显着改善了PC-12细胞的细胞活力和皮质酮诱导的损伤。