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Step by Step about Germ Cells Development in Canine
Animals ( IF 3 ) Pub Date : 2021-02-25 , DOI: 10.3390/ani11030598
Aline Fernanda de Souza , Naira Caroline Godoy Pieri , Daniele dos Santos Martins

Primordial germ cells (PGCs) have been described as precursors of gametes and provide a connection within generations, passing on the genome to the next generation. Failures in the formation of gametes/germ cells can compromise the maintenance and conservation of species. Most of the studies with PGCs have been carried out in mice, but this species is not always the best study model when transposing this knowledge to humans. Domestic animals, such as canines (canine), have become a valuable translational research model for stem cells and therapy. Furthermore, the study of canine germ cells opens new avenues for veterinary reproduction. In this review, the objective is to provide a comprehensive overview of the current knowledge on canine germ cells. The aspects of canine development and germ cells have been discussed since the origin, specifications, and development of spermatogonial canine were first discussed. Additionally, we discussed and explored some in vitro aspects of canine reproduction with germ cells, such as embryonic germ cells and spermatogonial stem cells.

中文翻译:

有关犬生殖细胞发育的分步指南

原始生殖细胞(PGC)被描述为配子的前体,并在世代之间提供了联系,并将基因组传给了下一代。配子/生殖细胞形成失败会损害物种的维持和保存。使用PGC进行的大多数研究都是在小鼠中进行的,但是当将此知识传递给人类时,该物种并非始终是最佳的研究模型。诸如犬(犬)之类的家畜已成为干细胞和治疗的有价值的转化研究模型。此外,对犬生殖细胞的研究为兽医繁殖开辟了新途径。在这篇综述中,目的是提供有关犬生殖细胞当前知识的全面概述。自起源以来就已经讨论了犬类发育和生殖细胞的各个方面,首先讨论了精原犬的规格和发展。此外,我们讨论并探索了用生殖细胞(例如胚胎生殖细胞和精原干细胞)进行犬繁殖的一些体外方面。
更新日期:2021-02-25
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