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Recent advances in culture-based gut microbiome research
International Journal of Medical Microbiology ( IF 4.1 ) Pub Date : 2021-02-25 , DOI: 10.1016/j.ijmm.2021.151485
Thomas C.A. Hitch , Afrizal Afrizal , Thomas Riedel , Antonios Kioukis , Dirk Haller , Ilias Lagkouvardos , Jörg Overmann , Thomas Clavel

Gut microbes affect the physiology of their hosts. Studying their diversity and functions is thus of utmost importance as it will open new avenues towards the discovery of new biomolecules and the treatment of diseases. Gut microbiome research is currently boosted by the unification of metagenomics, which has dominated the field in the last two decades, and cultivation, which is experiencing a renaissance. Each of these approaches has advantages and drawbacks that can be overcome if used synergistically. In this brief article, we summarize recent literature and own studies on the cultivation of gut microbes, provide a succinct status quo of cultured fractions and collections of isolates, and give short opinions on challenges and next steps to take.



中文翻译:

基于培养的肠道微生物组研究的最新进展

肠道微生物会影响其宿主的生理。因此,研究它们的多样性和功能至关重要,因为它将为发现新的生物分子和治疗疾病开辟新的途径。目前,肠胃微生物组的研究由于宏基因组学(在过去二十年中一直主导该领域)和栽培技术(正在经历复兴)的统一而得到了推动。这些方法中的每一种都有优点和缺点,如果协同使用可以克服。在这篇简短的文章中,我们总结了有关肠道微生物培养的最新文献和自己的研究,提供了培养级分和分离株集合的简明现状,并对挑战和下一步的措施给出了简短的见解。

更新日期:2021-03-07
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