Numerical analysis of optical biosensors made of very short-pillar (only one or two lattice constants high) liquid-infiltrated photonic crystals is presented. The small pillar height makes these photonic crystals amenable to fabrication by techniques such as nanoimprinting. Our biosensors can detect at least three different analytes (disease markers), individually or combinatorially in a single spectroscopic measurement. The resonance linewidths of our proposed device are narrow enough to accurately identify the relative concentrations of analytes within the biofluid, enabling our device to provide both qualitative and quantitative disease diagnoses. The minimal volume of fluid sample required for diagnosis is set by the micrometer-scale lattice constant of the photonic crystal. Using finite-difference time-domain simulations, we present detailed spectral characteristics for all possible combinations of analyte attachment to the photonic crystal nanopillars.

中文翻译：

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三维光子晶体短柱结构，用于高性能光学生物传感

提出了由非常短的柱子（只有一个或两个晶格常数高）液体渗透的光子晶体制成的光学生物传感器的数值分析。小的柱高使得这些光子晶体适合通过诸如纳米压印的技术来制造。我们的生物传感器可以在单个光谱测量中单独或组合检测至少三种不同的分析物（疾病标记）。我们提出的设备的共振线宽足够窄，可以准确识别生物流体中分析物的相对浓度，从而使我们的设备能够提供定性和定量疾病诊断。诊断所需的最小流体样品体积由光子晶体的微米级晶格常数设置。使用时域有限差分模拟