Oral drug administration has an important role in medical treatment. Attempts to develop drug microcarriers with desired features for extended duration and improved absorption is highly sought. Herein, inspired by the physical phenomenon of the Cheerios effect, a novel microfluidic electrospray microbubble carrier is presented that can suspend and actively adhere to the stomach for durable oral delivery. Compared with conventional fabrication methods, the present strategy shows stability and controllability of the product. Benefiting from their uniform hollow structure, the resultant microbubbles present the same behavior of the Cheerios and can float in the gastric juice, adhere and remain to the stomach wall, which thus enhance the duration and absorption of the loaded drugs. Based on these, it is demonstrated as a proof of concept that the dexamethasone‐loaded hollow microbubbles can be applied to oral administration and remain suspended and adhered to the stomach of murine for more than 1 d, showing good therapeutic effect in treating lupus erythematosus. Thus, it is believed that the microbubbles floating system will find important values in long‐term oral administration.

中文翻译：

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麦圈效应启发微泡作为悬浮和粘附的口服给药系统

口服药物在医疗中具有重要作用。人们高度寻求开发具有所需特征的药物微载体，以延长持续时间并改善吸收。在此，受Cheerios效应物理现象的启发，提出了一种新型微流控电喷雾微泡载体，它可以悬浮并主动粘附在胃上，以实现持久的口服递送。与传统的制造方法相比，本策略显示出产品的稳定性和可控性。得益于其均匀的中空结构，所得的微泡表现出与麦圈相同的行为，并且可以漂浮在胃液中，粘附并保留在胃壁上，从而增强所装载药物的持续时间和吸收。在此基础上，证明地塞米松空心微泡可用于口服给药，并在小鼠胃部保持悬浮和粘附1 d以上，在治疗红斑狼疮方面显示出良好的治疗效果。因此，相信微泡漂浮系统在长期口服给药中将具有重要价值。