The epidermal growth factor receptor (EGFR) plays an important role in the proliferation of various cancers, and the expression level of EGFR in tumor tissues can provide a basis for the diagnosis and prognosis. Improving the detection technology of EGFR to achieve high sensitivity and faster speed will benefit the diagnosis of many types of tumors. Trace biological samples can be sensitively measured with terahertz (THz) metamaterial devices. Here, a bow-tie array THz metamaterial biosensor is presented and modified with gold nanoparticles (GNPs) and EGFR antibodies for specific EGFR detection. The effect of the size of the GNP on the sensitivity enhancement was also analyzed. Enhanced sensing for EGFR was achieved with the assistance of GNPs and EGFR antibodies. Importantly, the metamaterial functionalized by GNPs and antibodies with a bigger GNP diameter achieves a greater resonance frequency shift. The proposed metamaterial biosensor can also realize tiny-volume EGFR solution detection. Our proposed technique can therefore sense EGFR sensitively with high speed, and can potentially be applied to achieve quick and accurate detection of EGFR related tumors.

中文翻译：

---

金纳米颗粒增强太赫兹超材料生物传感器对 EGFR 的检测

表皮生长因子受体（EGFR）在多种癌症的增殖中发挥着重要作用，肿瘤组织中EGFR的表达水平可以为诊断和预后提供依据。改进EGFR的检测技术，实现更高的灵敏度和更快的速度，将有利于多种类型肿瘤的诊断。可以使用太赫兹 (THz) 超材料设备灵敏地测量痕量生物样品。在这里，提出了一种领结阵列太赫兹超材料生物传感器，并用金纳米粒子 (GNP) 和 EGFR 抗体进行了修改，用于特异性 EGFR 检测。还分析了国民生产总值规模对敏感性增强的影响。在 GNP 和 EGFR 抗体的帮助下，增强了 EGFR 的传感能力。重要的是，由 GNP 和具有较大 GNP 直径的抗体功能化的超材料实现了更大的共振频移。所提出的超材料生物传感器还可以实现微小体积的EGFR溶液检测。因此，我们提出的技术可以灵敏、高速地检测 EGFR，并有可能用于实现 EGFR 相关肿瘤的快速、准确检测。