Abstract

Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the function of these epitranscriptomic marks. Here, we will review recent advances and breakthroughs achieved by NMR spectroscopy, sequencing, and mass spectrometry of the epitranscriptome.

中文翻译：

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RNA 修饰的仪器分析

摘要

来自生命各个领域的生物体都投入了大量的能量来将 RNA 修饰引入迄今为止研究的几乎所有转录本中。RNA 的仪器分析可以集中在修饰的残基上并揭示这些表观转录组标记的功能。在这里，我们将回顾最近的进展和突破，这些进展和突破是通过表观转录组的 NMR 光谱、测序和质谱来实现的。