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Turning the spotlight on the oligosaccharide chain of GM1 ganglioside
Glycoconjugate Journal ( IF 3 ) Pub Date : 2021-02-23 , DOI: 10.1007/s10719-021-09974-y
Elena Chiricozzi 1 , Erika Di Biase 1 , Giulia Lunghi 1 , Maria Fazzari 1 , Nicoletta Loberto 1 , Massimo Aureli 1 , Laura Mauri 1 , Sandro Sonnino 1
Affiliation  

It is well over a century that glycosphingolipids are matter of interest in different fields of research. The hydrophilic oligosaccharide and the lipid moiety, the ceramide, both or separately have been considered in different moments as the crucial portion of the molecule, responsible for the role played by the glycosphingolipids associated to the plasma-membranes or to any other subcellular fraction. Glycosphingolipids are a family of compounds characterized by thousands of structures differing in both the oligosaccharide and the ceramide moieties, but among them, the nervous system monosialylated glycosphingolipid GM1, belonging to the group of gangliosides, has gained particular attention by a multitude of Scientists. In recent years, a series of studies have been conducted on the functional roles played by the hydrophilic part of GM1, its oligosaccharide, that we have named “OligoGM1”. These studies allowed to shed new light on the mechanisms underlying the properties of GM1 defining the role of the OligoGM1 in determining precise interactions with membrane proteins instrumental for the neuronal functions, leaving to the ceramide the role of correctly positioning the GM1 in the membrane crucial for the oligosaccharide-protein interactions. In this review we aim to report the recent studies on the cascade of events modulated by OligoGM1, as the bioactive portion of GM1, to support neuronal differentiation and trophism together with preclinical studies on its potential to modify the progression of Parkinson’s disease.



中文翻译:

将焦点转向 GM1 神经节苷脂的寡糖链

一个多世纪以来,鞘糖脂在不同的研究领域都引起了人们的兴趣。亲水性寡糖和脂质部分,即神经酰胺,在不同的时刻都被认为是分子的关键部分,负责与质膜或任何其他亚细胞部分相关的鞘糖脂所起的作用。鞘糖脂是一类化合物,其特征在于寡糖和神经酰胺部分具有数千种不同的结构,但其中神经系统单唾液酸化鞘糖脂 GM1 属于神经节苷脂类,受到众多科学家的特别关注。近年来,针对 GM1 的亲水部分所发挥的功能作用进行了一系列研究,它的寡糖,我们称之为“OligoGM1”。这些研寡糖-蛋白质相互作用。在这篇综述中,我们旨在报告最近关于 OligoGM1 调节的级联事件的研究,作为 GM1 的生物活性部分,以支持神经元分化和营养,以及关于其改变帕金森病进展的潜力的临床前研究。这些研寡糖-蛋白质相互作用。在这篇综述中,我们旨在报告最近关于 OligoGM1 调节的级联事件的研究,作为 GM1 的生物活性部分,以支持神经元分化和营养,以及关于其改变帕金森病进展的潜力的临床前研究。这些研寡糖-蛋白质相互作用。在这篇综述中,我们旨在报告最近关于 OligoGM1 调节的级联事件的研究,作为 GM1 的生物活性部分,以支持神经元分化和营养,以及关于其改变帕金森病进展的潜力的临床前研究。将 GM1 正确定位在膜中的作用留给神经酰胺,这对于寡糖-蛋白质相互作用至关重要。在这篇综述中,我们旨在报告最近关于 OligoGM1 调节的级联事件的研究,作为 GM1 的生物活性部分,以支持神经元分化和营养,以及关于其改变帕金森病进展的潜力的临床前研究。将 GM1 正确定位在膜中的作用留给神经酰胺,这对于寡糖-蛋白质相互作用至关重要。在这篇综述中,我们旨在报告最近关于 OligoGM1 调节的级联事件的研究,作为 GM1 的生物活性部分,以支持神经元分化和营养,以及关于其改变帕金森病进展的潜力的临床前研究。

更新日期:2021-02-23
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