Post-transcriptional processing of RNAs plays important roles in a variety of physiological and pathological processes. These processes can be precisely controlled by a series of RNA binding proteins and cotranscriptionally regulated by transcription factors as well as histone modifications. With the rapid development of high-throughput sequencing techniques, multiomics data have been broadly used to study the mechanisms underlying the important biological processes. However, how to use these high-throughput sequencing data to elucidate the fundamental regulatory roles of post-transcriptional processes is still of great challenge. This review summarizes the regulatory mechanisms of post-transcriptional processes and the general principles and approaches to dissect these mechanisms by integrating multiomics data as well as public resources.

中文翻译：

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转录组数据的综合分析揭示了转录后调控的机制

RNA 的转录后加工在多种生理和病理过程中发挥着重要作用。这些过程可以由一系列 RNA 结合蛋白精确控制，并由转录因子和组蛋白修饰进行共转录调控。随着高通量测序技术的快速发展，多组学数据已被广泛用于研究重要生物过程的机制。然而，如何利用这些高通量测序数据来阐明转录后过程的基本调控作用仍然是一个巨大的挑战。本综述总结了转录后过程的调控机制，以及通过整合多组学数据和公共资源来剖析这些机制的一般原则和方法。